Impact of intracranial artery calcification on cerebral hemodynamic changes.

Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 1302751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1920 (Electronic) Linking ISSN: 00283940 NLM ISO Abbreviation: Neuroradiology Subsets: MEDLINE

Original Publication: Berlin, New York, Springer-Verlag.

Ultrasonography, Doppler, Transcranial*; Basilar Artery/*diagnostic imaging ; Basilar Artery/*physiopathology ; Hemodynamics/*physiology ; Middle Cerebral Artery/*diagnostic imaging ; Middle Cerebral Artery/*physiopathology ; Stroke/*diagnostic imaging ; Stroke/*physiopathology ; Vascular Calcification/*diagnostic imaging ; Vascular Calcification/*physiopathology ; Vertebral Artery/*diagnostic imaging ; Vertebral Artery/*physiopathology; Aged ; Blood Flow Velocity/physiology ; Female ; Humans ; Male ; Prospective Studies ; Pulsatile Flow/physiology ; Risk Factors

Purpose: Intracranial artery calcification (IAC) has been demonstrated to be correlated with ischemic stroke, cognitive decline, and other vascular events by accumulating evidences from both Western and Asian populations. The proposed study aimed to investigate its potential mechanisms by evaluating the blood flow velocity and pulsatility index (PI) of cerebral arteries.
Methods: Consecutive ischemic stroke patients admitted to the Prince of Wales Hospital were recruited after excluding those with atrial fibrillation or poor temporal window. Quantitative measurements of IAC severity were assessed on brain CT scans. Transcranial Doppler (TCD) ultrasonography was performed to evaluate the blood flow velocity of the middle cerebral artery (MCA) and vertebral-basilar artery (VBA).
Results: In total, 318 patients were analyzed. Spearman's correlation analysis demonstrated both high MCA systolic flow velocity and high MCA PI were correlated with IAC Agatston score, p < 0.001 individually. Similar correlation was also found between IAC Agatston score and high VBA velocity/high VBA PI, p ≤ 0.001 individually. Multiple logistic regression analysis showed IAC Agatston score was an independent risk factor for high MCA velocity (OR 1.533; 95% CI 1.235-1.903), high VBA velocity (OR 1.964; 95% CI 1.381-2.794), and high VBA PI (OR 1.200; 95% CI 1.016-1.418), respectively.
Conclusion: Heavier IAC might cause generalized artery flow velocity changes and increased pulsatility index, which may indicate high resistance within cerebrovasculature.

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11120161 Health and Medical Research Fund

Keywords: Computed tomography cerebral blood flow velocity; Intracranial arterial calcification; Ischemic stroke; Pulsatility index

Date Created: 20180211 Date Completed: 20180823 Latest Revision: 20181113

20221213

10.1007/s00234-018-1988-2

29426978