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Cutaneous microcirculation during operations with a cardiopulmonary bypass.

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  • Author(s): Saemann L;Saemann L; Wenzel F; Wenzel F
  • Source:
    Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2018; Vol. 69 (1-2), pp. 13-21.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: SAGE Publications Country of Publication: United States NLM ID: 9709206 Publication Model: Print Cited Medium: Internet ISSN: 1875-8622 (Electronic) Linking ISSN: 13860291 NLM ISO Abbreviation: Clin Hemorheol Microcirc Subsets: MEDLINE
    • Publication Information:
      Publication: 2025- : [Thousand Oaks, CA] : SAGE Publications
      Original Publication: Amsterdam ; Washington, DC : IOS Press, c1997-
    • Subject Terms:
      Cardiac Surgical Procedures/*methods ; Cardiopulmonary Bypass/*methods ; Heart Arrest, Induced/*methods ; Hemodynamics/*drug effects ; Microcirculation/*physiology; Female ; Humans ; Male ; Middle Aged ; Prospective Studies
    • Abstract:
      Background: Cutaneous microcirculation (cMC) is influenced by many factors. In cardiac surgery, most operations are performed with a cardiopulmonary bypass (CPB) and cardiac arrest induced by cardioplegic solutions.
      Objectives: Aim of this study was to examine a correlation between cMC and hemodynamic parameters in patients undergoing heart surgery with two different cardioplegic solutions.
      Methods: 20 patients were included and divided into Histidine-Tryptophane-α-Ketoglutarate solution- (HTK, n = 10) and blood cardioplegia- (BCP, n = 10) groups. With initiation of CPB, cMC was continuously monitored with Laser-Doppler-Perfusion (LDP) until termination of CPB. Additionally, we measured hemoglobin-concentration (HbC) with a Blood-Parameter-Monitoring-System.
      Results: LDP pulsation was almost equal before and after CPB and decreased during aortic cross clamping. The following factors influenced LDP: central venous pressure (CVP), mean arterial pressure (MAP), total peripheral resistance (TPR) and flow of the heart-lung machine. We measured relative LDP and HbC (RLDP; RHbC). Five and 25 min after administration of cardioplegia, RLDP (1.22±0.8; 1.17±0.94) and RHbC (0.92±0.06; 0.96±0.09) in the HTK-group were lower than in the BCP-group: RLDP (1.58±1.11; 1.58±2.2) and RHbC (1.00±0.05; 0.99±0.13). HTK-patients with a body surface area (BSA) <2 m2 showed a lower RLDP (0.75±0.50), than patients over 2 m2 (RLDP = 1.64±0.97).
      Conclusions: The cMC is influenced by CPB. Cutaneous LDP monitoring is a non-invasive method, for estimating hemodynamics intraoperatively.
    • Contributed Indexing:
      Keywords: Bretschneider; Calafiore; Extracorporeal circulation; Laser-Doppler-Flow; Laser-Doppler-Perfusion; cardioplegia; cardiopulmonary bypass; heart-lung machine; hemodynamics; microcirculation
    • Publication Date:
      Date Created: 20180410 Date Completed: 20180615 Latest Revision: 20181202
    • Publication Date:
      20260130
    • Accession Number:
      10.3233/CH-189102
    • Accession Number:
      29630531