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The effect of rebranding generic medicines on drug efficacy and side effects.

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  • Additional Information
    • Source:
      Publisher: Routledge Country of Publication: England NLM ID: 8807983 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-8321 (Electronic) Linking ISSN: 08870446 NLM ISO Abbreviation: Psychol Health Subsets: MEDLINE
    • Publication Information:
      Publication: <2010-> : Abingdon, Oxon : Routledge
      Original Publication: Chur ; New York : Harwood Academic Publishers ; London : distributed by STBS Ltd., c1987-
    • Subject Terms:
      Adrenergic beta-Antagonists/*adverse effects ; Drug-Related Side Effects and Adverse Reactions/*metabolism ; Drugs, Generic/*therapeutic use; Adult ; Drugs, Generic/pharmacology ; Female ; Humans ; Male ; Young Adult
    • Abstract:
      Objective: Branded medicines have a greater placebo effect, resulting in a heightened therapeutic response, whereas generics are associated with greater side effect reporting. These two studies investigated whether enhancing the appearance of a generic medicine could increase placebo and decrease nocebo responding. Design: Two experimental studies allegedly examining the effect of β-blockers (actually placebos) for pre-examination anxiety. In Study 1, participants received either a generic β-blocker with enhanced packaging, a plainly packaged generic or a branded β-blocker. Study 2 compared an enhanced packaging generic to a plainly packaged generic β-blocker. Main outcomes measures: Blood pressure, heart rate, anxiety and the number of symptoms and side effects reported. Results: Study 1 found no differences between the three groups for blood pressure, heart rate, or anxiety. Study 2 showed similar results but a significant difference in anxiety was found with the plain generic group experiencing a greater reduction in anxiety than the enhanced generic group. No differences in symptoms or side effects were found in either study. Conclusions: While the sample characteristics and familiarity of the medicines may have influenced the findings, we found no evidence that enhancing the branding of generic medicines improved response to the medication or reduced side effects.
    • Contributed Indexing:
      Keywords: Generic medicines; branding; nocebo; placebo
    • Accession Number:
      0 (Adrenergic beta-Antagonists)
      0 (Drugs, Generic)
    • Publication Date:
      Date Created: 20190522 Date Completed: 20200407 Latest Revision: 20200408
    • Publication Date:
      20250114
    • Accession Number:
      10.1080/08870446.2019.1616088
    • Accession Number:
      31112047