Precise capture and dynamic relocation of nanoparticulate biomolecules through dielectrophoretic enhancement by vertical nanogap architectures.

Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Original Publication: [London] : Nature Pub. Group

Biosensing Techniques*; Nanoparticles/*chemistry ; Nanostructures/*chemistry ; Nanotechnology/*methods; Bacillus subtilis ; Biocompatible Materials ; Computer Simulation ; Dimethylpolysiloxanes/chemistry ; Electrochemistry ; Electrodes ; Equipment Design ; Fungi ; Kinetics ; Lipids/chemistry ; Materials Testing ; Osmosis ; Reproducibility of Results

Toward the development of surface-sensitive analytical techniques for biosensors and diagnostic biochip assays, a local integration of low-concentration target materials into the sensing region of interest is essential to improve the sensitivity and reliability of the devices. As a result, the dynamic process of sorting and accurate positioning the nanoparticulate biomolecules within pre-defined micro/nanostructures is critical, however, it remains a huge hurdle for the realization of practical surface-sensitive biosensors and biochips. A scalable, massive, and non-destructive trapping methodology based on dielectrophoretic forces is highly demanded for assembling nanoparticles and biosensing tools. Herein, we propose a vertical nanogap architecture with an electrode-insulator-electrode stack structure, facilitating the generation of strong dielectrophoretic forces at low voltages, to precisely capture and spatiotemporally manipulate nanoparticles and molecular assemblies, including lipid vesicles and amyloid-beta protofibrils/oligomers. Our vertical nanogap platform, allowing low-voltage nanoparticle captures on optical metasurface designs, provides new opportunities for constructing advanced surface-sensitive optoelectronic sensors.

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0 (Biocompatible Materials)
0 (Dimethylpolysiloxanes)
0 (Lipids)
63148-62-9 (baysilon)

Date Created: 20200606 Date Completed: 20200818 Latest Revision: 20210604

20231215

PMC7272609

10.1038/s41467-020-16630-w

32499540