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Three new compounds from the rhizome of Ligusticum chuanxiong and their anti-inflammation activities.

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  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print Cited Medium: Internet ISSN: 1477-2213 (Electronic) Linking ISSN: 10286020 NLM ISO Abbreviation: J Asian Nat Prod Res Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: [Newark, N.J.?] : Harwood Academic Publishers,
    • Subject Terms:
      Drugs, Chinese Herbal* ; Ligusticum*; Humans ; Inflammation ; Molecular Structure ; Rhizome
    • Abstract:
      Phytochemical investigation of the rhizome of Ligusticum chuanxiong Hort led to the isolation and identification of three new compounds, chuanxiongoside A, (2 E ,4 E )-8-(6- O -inositolyl)-8-oxo-2,7-dimethyl-octadienoic acid ( 2 ), chuanxiongoside C ( 3 ). The structures of these compounds were unambiguously established by HR-ESI-MS, UV, IR, CD, NMR spectral data and comparison to reported data. All the isolated compounds ( 1 - 3 ) were investigated for their inhibitory effects on nitric oxide (NO) production in LPS-induced RAW 264.7 cells. All compounds showed excellent inhibition of NO production stronger than curcumin. [Formula: see text].
    • Contributed Indexing:
      Keywords: Ligusticum chuanxiong; Apiaceae; anti-inflammation; structure identification
    • Accession Number:
      0 (Drugs, Chinese Herbal)
    • Publication Date:
      Date Created: 20200822 Date Completed: 20200825 Latest Revision: 20200825
    • Publication Date:
      20231215
    • Accession Number:
      10.1080/10286020.2020.1803291
    • Accession Number:
      32820957