Phase Separation in Germ Cells and Development.

Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE

Original Publication: Cambridge, Mass. : Cell Press, c2001-

Cell Differentiation/*physiology ; Germ Cells/*metabolism ; RNA/*genetics ; Spermatozoa/*metabolism; Animals ; Cell Lineage/physiology ; Drosophila Proteins/metabolism ; Humans ; Male

The animal germline is an immortal cell lineage that gives rise to eggs and/or sperm each generation. Fusion of an egg and sperm, or fertilization, sets off a cascade of developmental events capable of producing an array of different cell types and body plans. How germ cells develop, function, and eventually give rise to entirely new organisms is an important question in biology. A growing body of evidence suggests that phase separation events likely play a significant and multifaceted role in germ cells and development. Here, we discuss the organization, dynamics, and potential functions of phase-separated compartments in germ cells and examine the various ways in which phase separation might contribute to the development of multicellular organisms.
(Copyright © 2020 Elsevier Inc. All rights reserved.)

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R01 GM088289 United States GM NIGMS NIH HHS; R01 GM132286 United States GM NIGMS NIH HHS; R21 AG061850 United States AG NIA NIH HHS

Keywords: biomolecular condensates; development; germ granules; phase separation

0 (Drosophila Proteins)
63231-63-0 (RNA)

Date Created: 20201002 Date Completed: 20210311 Latest Revision: 20211013

20231215

PMC7572804

10.1016/j.devcel.2020.09.004

33007213