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Impact of Dim Light at Night on Urinary 6-Sulphatoxymelatonin Concentrations and Sleep in Healthy Humans.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, [2000-
    • Subject Terms:
      Health* ; Light*; Circadian Rhythm/*radiation effects ; Melatonin/*analogs & derivatives ; Sleep/*radiation effects; Creatinine/urine ; Melatonin/urine ; Female ; Humans ; Male ; Young Adult
    • Abstract:
      Artificial light at night can have negative effects on human wellbeing and health. It can disrupt circadian rhythms, interfere with sleep, and participate in the progress of civilisation diseases. The aim of the present study was to explore if dim artificial light during the entire night (ALAN) can affect melatonin production and sleep quality in young volunteers. We performed two experiments in real-life home-based conditions. Young volunteers (n = 33) were exposed to four nights of one lux ALAN or two nights of five lux ALAN. Melatonin production, based on 6-sulphatoxymelatonin/creatinine concentrations in urine, and sleep quality, based on actimetry, were evaluated. Exposure to ALAN one lux during the entire night did not suppress aMT6s/creatinine concentrations but did aggravate sleep quality by increasing sleep fragmentation and one-minute immobility. ALAN up to five lux reduced melatonin biosynthesis significantly and interfered with sleep quality, as evidenced by an increased percentage of one-minute immobility and a tendency of increased fragmentation index. Our results show that people are more sensitive to low illuminance during the entire night, as previously expected. ALAN can interfere with melatonin production and sleep quality in young, healthy individuals, and both processes have different sensitivities to light.
    • References:
      J Neurosci. 2003 Aug 6;23(18):7093-106. (PMID: 12904470)
      Cell Rep. 2019 Dec 10;29(11):3349-3355.e2. (PMID: 31825819)
      Sleep. 2003 May 1;26(3):337-41. (PMID: 12749556)
      Mol Cell Endocrinol. 2012 Apr 4;351(2):152-66. (PMID: 22245784)
      J Exp Zool A Ecol Integr Physiol. 2018 Oct;329(8-9):387-393. (PMID: 30371014)
      Chronobiol Int. 2014 Nov;31(9):976-82. (PMID: 25025617)
      J Neural Transm (Vienna). 2000;107(3):271-9. (PMID: 10821436)
      J Affect Disord. 2019 Oct 1;257:314-320. (PMID: 31302520)
      J Clin Sleep Med. 2008 Feb 15;4(1):66-9. (PMID: 18350967)
      J Biol Rhythms. 2015 Aug;30(4):351-4. (PMID: 26017927)
      J Pineal Res. 2002 Nov;33(4):198-203. (PMID: 12390501)
      Clin Chem. 1987 Aug;33(8):1343-8. (PMID: 3608151)
      J Physiol. 2000 Aug 1;526 Pt 3:695-702. (PMID: 10922269)
      Endocr Rev. 2018 Dec 1;39(6):990-1028. (PMID: 30215696)
      Integr Cancer Ther. 2009 Dec;8(4):347-53. (PMID: 20042410)
      Int J Mol Sci. 2020 Mar 23;21(6):. (PMID: 32210175)
      Nature. 2020 Mar;579(7800):609-614. (PMID: 32040955)
      Ergonomics. 1979 Jan;22(1):79-91. (PMID: 436816)
      Crit Rev Eukaryot Gene Expr. 2016;26(1):49-62. (PMID: 27278885)
      Cell Tissue Res. 2002 Jul;309(1):151-62. (PMID: 12111545)
      CA Cancer J Clin. 2014 May-Jun;64(3):207-18. (PMID: 24604162)
      J Pineal Res. 1998 May;24(4):230-8. (PMID: 9572533)
      JAMA Psychiatry. 2020 Jul 8;:. (PMID: 32639562)
      Chronobiol Int. 2015;32(8):1029-48. (PMID: 26374931)
      Front Biosci (Schol Ed). 2013 Jan 01;5:743-53. (PMID: 23277083)
      Chronobiol Int. 2019 May;36(5):657-671. (PMID: 30793958)
      Proc Natl Acad Sci U S A. 2011 Sep 13;108 Suppl 3:15602-8. (PMID: 21536890)
      Sleep Med. 2001 Sep;2(5):389-96. (PMID: 14592388)
      Environ Health Perspect. 1996 Mar;104 Suppl 1:135-40. (PMID: 8722117)
      J Biol Rhythms. 1989 Summer;4(2):161-85. (PMID: 2519587)
      Interface Focus. 2020 Jun 6;10(3):20190098. (PMID: 32382406)
      Cell. 2018 Sep 20;175(1):71-84.e18. (PMID: 30173913)
      J Mol Cell Cardiol. 2014 Jan;66:1-11. (PMID: 24200829)
      Sci Adv. 2016 Jun 10;2(6):e1600377. (PMID: 27386582)
      Sci Rep. 2016 Jun 07;6:26756. (PMID: 27272736)
      Chronobiol Int. 2015;32(9):1294-310. (PMID: 26375320)
      Ann Clin Biochem. 1988 May;25 ( Pt 3):298-303. (PMID: 3400987)
      Front Endocrinol (Lausanne). 2019 Jul 16;10:391. (PMID: 31379733)
      J Clin Endocrinol Metab. 2013 Jan;98(1):337-44. (PMID: 23118419)
      Int J Mol Sci. 2019 Jun 28;20(13):. (PMID: 31261700)
      Rev Reprod. 1998 Jan;3(1):13-22. (PMID: 9509985)
      Philos Trans R Soc Lond B Biol Sci. 2015 May 5;370(1667):. (PMID: 25780244)
      Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):12019-12024. (PMID: 31138694)
      Chronobiol Int. 2016;33(1):117-23. (PMID: 26654880)
    • Grant Information:
      APVV-17-0178, APVV- 18- 0174 Agentúra na Podporu Výskumu a Vývoja
    • Contributed Indexing:
      Keywords: 6-sulphatoxymelatonin; ALAN; aMT6s/creatinine; chronodisruption; circadian; light pollution; melatonin; sleep quality
    • Accession Number:
      2208-40-4 (6-sulfatoxymelatonin)
      AYI8EX34EU (Creatinine)
      JL5DK93RCL (Melatonin)
    • Publication Date:
      Date Created: 20201022 Date Completed: 20210223 Latest Revision: 20210223
    • Publication Date:
      20260130
    • Accession Number:
      PMC7588991
    • Accession Number:
      10.3390/ijms21207736
    • Accession Number:
      33086713