Feline and canine Merkel cell carcinoma: A case series and discussion on cellular origin.

Publisher: Blackwell Country of Publication: England NLM ID: 101185242 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5829 (Electronic) Linking ISSN: 14765810 NLM ISO Abbreviation: Vet Comp Oncol Subsets: MEDLINE

Original Publication: Oxford, UK : Blackwell, [2003]-

Carcinoma, Merkel Cell*/veterinary ; Cat Diseases* ; Dog Diseases* ; Skin Neoplasms*/veterinary; Animals ; B-Lymphocytes ; Cats ; Dogs

Merkel cell carcinoma (MCC) is in humans and cats a malignant cutaneous neuroendocrine carcinoma, whereas in dogs it possibly has a more benign behaviour. It may be cytologically confused with round cell tumours such as lymphoma because of its striking cytomorphologic similarity. Although MCC is considered to arise from Merkel cells, recent findings indicated that primitive (epi-)dermal stem cells, early B-cells or dermal fibroblasts were the origin of human MCC. The aim of our study was to evaluate a possible lymphoid origin in feline and canine MCCs. Specific analysis of CD3, PAX-5, KIT and PARR assay were performed in 3 feline and 3 canine MCCs. All MCCs (6/6) were negative for CD3 and PAX-5. KIT was expressed in all MCCs (6/6). Assessment of clonality by PARR assay exhibited a polyclonal B- and T-cell receptor rearrangement in all five cases tested. In conclusion, a lymphoid origin of feline and canine MCCs could not be demonstrated. This is in contrast with human MCCs, that often express early B-cell lineage markers.
(© 2020 The Authors. Veterinary and Comparative Oncology published by John Wiley & Sons Ltd.)

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Keywords: Merkel cell carcinoma; comparative; origin

Date Created: 20201229 Date Completed: 20220121 Latest Revision: 20220121

20240513

PMC8248026

10.1111/vco.12672

33372715