Risk factors and outcomes of cardiovascular disease readmission within the first year after dialysis in peritoneal dialysis patients.

Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

Publication: London : Informa Healthcare
Original Publication: New York, N.Y. : M. Dekker, c1987-

Cardiovascular Diseases/*mortality ; Kidney Failure, Chronic/*therapy ; Patient Readmission/*statistics & numerical data ; Peritoneal Dialysis, Continuous Ambulatory/*adverse effects ; Peritoneal Dialysis, Continuous Ambulatory/*mortality; Adult ; Age Factors ; Aged ; Cardiovascular Diseases/etiology ; Cause of Death ; China/epidemiology ; Female ; Humans ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/mortality ; Male ; Middle Aged ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Survival Analysis ; Time Factors

Background: In the first year of dialysis, patients are vulnerable to cardiovascular disease (CVD) hospitalization, but knowledge regarding the risk factors and long-term outcomes of cardiovascular readmission within the first year after dialysis in incident continuous ambulatory peritoneal dialysis (CAPD) patients is limited.
Methods: This retrospective cohort study was conducted in incident CAPD patients. The demographic characteristics, laboratory parameters, and CVD readmission were collected and analyzed. The primary outcome was all-cause mortality, and the secondary outcomes included CVD mortality, infection-related mortality and technique failure. A logistic regression was used to identify the risk factors associated with CVD readmission within the first year after dialysis. Cox proportional hazards models were used to evaluate the association between CVD readmission and the outcomes.
Results: In total, 1589 peritoneal dialysis (PD) patients were included in this study, of whom 120 (7.6%) patients had at least one episode of CVD readmission within the first year after dialysis initiation. Advanced age, CVD history, and a lower level of serum albumin were independently associated with CVD readmission. CVD readmission within the first year after dialysis was significantly associated with all-cause (HR 2.66, 95%CI 1.91-3.70, p  < 0.001) and CVD (HR 3.42, 95%CI 2.20-5.31, p  < 0.001) mortality, but not infection-related mortality or technique failure, after adjusting for confounders.
Conclusions: Our findings suggest that an advanced age, a history of CVD, and a lower level of serum albumin were independently associated with CVD readmission. Moreover, CVD readmission was associated with all-cause and cardiovascular mortality in incident CAPD patients.

Erratum in: Ren Fail. 2021 Dec;43(1):381. (PMID: 33615983)

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Keywords: Cardiovascular disease readmission; outcomes; peritoneal dialysis; risk factors

Date Created: 20210114 Date Completed: 20210913 Latest Revision: 20210913

20231215

PMC7808740

10.1080/0886022X.2020.1866009

33441045