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Expansion of inflammatory monocytes in periphery and infiltrated into thyroid tissue in Graves' disease.

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • Subject Terms:
      Graves Disease*/blood ; Graves Disease*/pathology ; Monocytes*/metabolism ; Monocytes*/pathology ; Thyroid Gland*/metabolism ; Thyroid Gland*/pathology; Adult ; B-Cell Activating Factor/blood ; Female ; Humans ; Inflammation/blood ; Inflammation/pathology ; Male ; Middle Aged
    • Abstract:
      Monocytes are important mediators of immune system and are reported to be altered in autoimmune disorders. Little is known about the pathological role of monocytes in Graves' disease (GD). Thus, we investigated monocytes in periphery and thyroid tissue in GD. Untreated GD patients were enrolled and followed up until remission. Monocytes were significantly increased and positively correlated with anti-thyrotropin receptor antibody (TRAb) in untreated GD (r counts  = 0.269, P < 0.001; r percentage  = 0.338, P < 0.001). Flow cytometry showed CD14++ CD16+ monocytes were increased and CD14++ CD16- monocytes were decreased in untreated GD (both P < 0.001). Skewed monocyte subsets were recovered in GD with remission. Serum B cell-activating factor (BAFF) was positively correlated with TRAb (r = 0.384 and P = 0.001). CD14++ CD16+ monocytes expressed higher level of BAFF in untreated GD (P < 0.05). The frequency of CD14+ monocytes and CD14+ CD16+ monocytes were significantly higher in GD thyroid tissue than in normal thyroid tissue (both P < 0.001). Our study suggested CD14++ CD16+ monocytes were significantly expanded and involved in the production of TRAb via secreting a higher level of BAFF in periphery. Besides, monocytes infiltrated into thyroid tissue and thus could serve as an important participant in GD pathogenesis.
    • References:
      J Transl Med. 2015 Jan 16;13:2. (PMID: 25592233)
      PLoS One. 2014 Oct 17;9(10):e109775. (PMID: 25329467)
      Horm Metab Res. 2015 Sep;47(10):727-34. (PMID: 26361259)
      J Clin Endocrinol Metab. 2012 Mar;97(3):943-50. (PMID: 22188745)
      Cell Immunol. 2014 May-Jun;289(1-2):135-9. (PMID: 24791698)
      Immunity. 2013 Feb 21;38(2):336-48. (PMID: 23352235)
      Rom J Intern Med. 2009;47(3):207-15. (PMID: 20446435)
      Front Immunol. 2019 May 24;10:1140. (PMID: 31178867)
      Immunol Res. 2014 Dec;60(2-3):277-88. (PMID: 25381481)
      Blood. 2011 Sep 22;118(12):e50-61. (PMID: 21803849)
      Nat Rev Immunol. 2009 Jul;9(7):491-502. (PMID: 19521398)
      Curr Opin Immunol. 2010 Dec;22(6):732-9. (PMID: 20970975)
      Immunity. 2008 Jul 18;29(1):138-49. (PMID: 18599325)
      Immunol Cell Biol. 2014 Jul;92(6):509-17. (PMID: 24638064)
      Immunity. 2007 Apr;26(4):519-31. (PMID: 17412618)
      Scand J Immunol. 2020 Jul;92(1):e12883. (PMID: 32243617)
      Expert Opin Investig Drugs. 2014 Sep;23(9):1285-94. (PMID: 25078871)
      J Immunol. 2002 Apr 1;168(7):3536-42. (PMID: 11907116)
      Arthritis Rheum. 2012 Mar;64(3):671-7. (PMID: 22006178)
      J Rheumatol. 2013 May;40(5):579-89. (PMID: 23547209)
      Endocr Rev. 2020 Dec 1;41(6):. (PMID: 32845332)
      Thyroid. 2015 Sep;25(9):1043-9. (PMID: 26214745)
      Thyroid. 2014 Mar;24(3):537-44. (PMID: 24032645)
      Front Immunol. 2020 Apr 29;11:594. (PMID: 32411125)
      Nephrol Dial Transplant. 2015 Jul;30(7):1122-232. (PMID: 25770168)
      Science. 2010 Feb 5;327(5966):656-61. (PMID: 20133564)
      Int J Mol Med. 1998 Jan;1(1):95-103. (PMID: 9852205)
      Nat Rev Dis Primers. 2020 Jul 2;6(1):52. (PMID: 32616746)
      Expert Opin Biol Ther. 2013 Feb;13(2):315-22. (PMID: 23268610)
      Blood. 2010 Oct 21;116(16):e74-80. (PMID: 20628149)
      Thyroid. 2016 Oct;26(10):1343-1421. (PMID: 27521067)
      Semin Immunol. 2006 Oct;18(5):305-17. (PMID: 16916610)
      Endocrinology. 2006 Oct;147(10):4561-8. (PMID: 16794009)
      J Clin Endocrinol Metab. 2012 May;97(5):E755-9. (PMID: 22399512)
    • Accession Number:
      0 (B-Cell Activating Factor)
      0 (TNFSF13B protein, human)
    • Publication Date:
      Date Created: 20210630 Date Completed: 20211105 Latest Revision: 20211105
    • Publication Date:
      20250114
    • Accession Number:
      PMC8242071
    • Accession Number:
      10.1038/s41598-021-92737-4
    • Accession Number:
      34188092