Outcomes and prognostic factors in canine epitheliotropic and nonepitheliotropic cutaneous T-cell lymphomas.

Publisher: Blackwell Country of Publication: England NLM ID: 101185242 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5829 (Electronic) Linking ISSN: 14765810 NLM ISO Abbreviation: Vet Comp Oncol Subsets: MEDLINE

Original Publication: Oxford, UK : Blackwell, [2003]-

Dog Diseases*/pathology ; Lymphoma, Non-Hodgkin*/veterinary ; Lymphoma, T-Cell, Cutaneous*/diagnosis ; Lymphoma, T-Cell, Cutaneous*/drug therapy ; Lymphoma, T-Cell, Cutaneous*/veterinary ; Skin Neoplasms*/diagnosis ; Skin Neoplasms*/veterinary; Animals ; Dogs ; Prognosis ; Retrospective Studies

Canine cutaneous lymphoma is an uncommon lymphoma in dogs. Most canine cutaneous lymphoma cases have a T-cell origin. Canine cutaneous T-cell lymphoma (CTCL) is classified into epitheliotropic and nonepitheliotropic cutaneous lymphomas, and each type of lymphoma is subclassified into several histological subtypes. Limited information is available regarding the prognostic significance of clinical variables and histopathological subtypes in dogs with CTCL. This retrospective study aimed to investigate the influence of clinical variables and histopathological subtypes on the prognosis of dogs with CTCL. Forty-six dogs diagnosed with CTCL by histopathological examination were included. Histopathological specimens were reexamined and classified into CTCL subtypes. The influence of the type of skin lesion, histopathological subtype, haematological examination results and treatment response on the overall survival time (OS) was examined. Thirty-one dogs were diagnosed with epitheliotropic CTCL (mycosis fungoides in 28 dogs; pagetoid reticulosis in 3 dogs) and 15 dogs were diagnosed with nonepitheliotropic CTCL (anaplastic large T-cell lymphoma in 6 dogs; peripheral T-cell lymphoma, not otherwise specified, in 9 dogs). The OS of dogs diagnosed with epitheliotropic CTCL (141 days) was significantly shorter than that of dogs diagnosed with nonepitheliotropic CTCL (374 days). As clinical variables, the presence of neoplastic lymphocytes in peripheral blood, thrombocytopenia and initial chemotherapeutic response was related to prognosis. Our results demonstrated that histopathological subtype and several clinical variables were found to influence the prognosis of dogs with CTCL.
(© 2021 John Wiley & Sons Ltd.)

Dobson JM, Samuel S, Milstein H, Rogers K, Wood JLN. Canine neoplasia in the UK: estimates of incidence rates from a population of insured dogs. J Small Anim Pract. 2002;43(6):240-246.
Dorn CR, Taylor DON, Schneider R, Hibbard HH, Klauber MR. Survey of animal neoplasms in alameda contra costa counties, California. II. Cancer morbidity in dogs and cats from Alameda County. J Natl Cancer Inst. 1968;40(2):307-318.
Dorn CR, Taylor DON, Schneider R. The epidemiology of canine leukemia and lymphoma. Bibl Haematol 1970;(36):403-415.
Mellanby RJ, Herrtage ME, Dobson JM. Treatment of canine lymphoma by veterinarians in first opinion practice in England. J Small Anim Pract. 2002;43(5):198-202.
Merlo DF, Rossi L, Pellegrino C, et al. Cancer incidence in pet dogs: findings of the animal tumor registry of Genoa, Italy. J Vet Intern Med. 2008;22(4):976-984.
Kaiser HE. In: Kaiser HE, ed. Neoplasms-Comparative Pathology in Animals, Plants and Man. Baltimore: Williams & Wilkins; 1981.
Moulton JE, Harvey JW. In: Moulton JE, ed. Tumors of Domestic Animals. 3rd ed. California: University of California Press; 1990.
Fournel-Fleury C, Ponce F, Felman P, et al. Canine T-cell lymphomas: a morphological, immunological, and clinical study of 46 new cases. Vet Pathol. 2002;39(1):92-109.
Moore PF, Olivry T. Cutaneous lymphomas in companion animals. Clin Dermatol. 1994;12(4):499-505.
Chan CM, Fribmerger AE, Moore AS. Clinical outcome and prognosis of dogs with histopathological features consistent with epitheliotropic lymphoma: a retrospective study of 148 cases (2003-2015) in Australia. Vet Dermatol. 2018;29(2):154-e59.
Williams LE, Rassnick KM, Power HT, et al. CCNU in the treatment of canine epitheliotropic lymphoma. J Vet Intern Med. 2006;20(1):136-143.
Risbon RE, de Lorimier LP, Skorupski K, et al. Response of canine cutaneous epitheliotropic lymphoma to lomustine (CCNU): a retrospective study of 46 cases (1999-2004). J Vet Intern Med. 2006;20(6):1389-1397.
Valli VEO, Kiupel M, In: Maxie MG, ed. Pathology of Domestic Animals. Vol. 3, Missouri: Elsevier; 2016:102-268.
Willemze R, Jansen PM, Cerroni L, et al. Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC cutaneous lymphoma group study of 83 cases. Blood. 2008;111(2):838-845.
Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105(10):3768-3785.
Fontaine J, Heimann M, Day MJ. Canine cutaneous epitheliotropic T-cell lymphoma: a review of 30 cases. Vet Dermatol. 2010;21(3):267-275.
Fontaine J, Bovens C, Bettenay S, Mueller RS. Canine cutaneous epitheliotropic T-cell lymphoma: a review. Vet Comp Oncol. 2009;7(1):1-14.
Moore PF, Affolter VK, Graham PS, Hirt B. Canine epitheliotropic cutaneous T-cell lymphoma: an investigation of T-cell receptor immunophenotype, lesion topography and molecular clonality. Vet Dermatol. 2009;20(5-6):569-576.
Willcock BP, Yager JA. The behaviour of epidermotropic lymphoma in twenty-five dogs. Can Vet J. 1989;30(9):754-756.
Moore PF, Affolter VK, Keller SM. Canine inflamed nonepitheliotropic cutaneous T-cell lymphoma: a diagnostic conundrum. Vet Dermatol. 2013;24(1):204-211.
Nguyen SM, Thamm DH, Vail DM, London CA. Response evaluation criteria for solid tumours in dogs (v1.0): a veterinary cooperative oncology group (VCOG) consensus document. Vet Comp Oncol. 2015;13(3):176-183.
Goto-Koshino Y, Mochizuki H, Sato M, et al. Construction of a multicolor GeneScan analytical system to detect clonal rearrangements of immunoglobulin and T cell receptor genes in canine lymphoid tumors. Vet Immunol Immunopathol. 2015;165(1-2):138-144.
Garrett LD, Thamm DH, Chun R, Dudley R, Vail DM. Evaluation of a 6-month chemotherapy protocol with no maintenance therapy for dogs with lymphoma. J Vet Intern Med. 2002;16(6):704-709.
Saba CF, Hafeman SD, Vail DM, Thamm DH. Combination chemotherapy with continuous L-asparaginase, lomustine, and prednisone for relapsed canine lymphoma. J Vet Intern Med. 2009;23(5):1058-1063.
Rütgen BC, Flickinger I, Wolfesberger B, et al. Cutaneous T-cell lymphoma-Sézary syndrome in a boxer. Vet Clin Pathol. 2016;45(1):172-178.
Laprais A, Olivry T. Is CCNU (lomustine) valuable for treatment of cutaneous epitheliotropic lymphoma in dogs? A critically appraised topic. BMC Vet Res. 2017;13(1):61.
De Lorimier LP. Updates on the management of canine epitheliotropic cutaneous T-cell lymphoma. Vet Clin North Am Small Anim Pract. 2006;36(1):213-228.
Moore PF, Olivry T, Naydan D. Canine cutaneous epitheliotropic lymphoma (mycosis fungoides) is a proliferative disorder of CD+8 T-cells. Am J Pathol. 1994;144(2):421-429.
Chimura N, Kondo N, Shibata S, et al. Gene transcription analysis in lesional skin of canine epitheliotropic cutaneous lymphoma using quantitative real-time RT-PCR. Vet Immunol Immunopathol. 2011;144(3-4):329-336.
Guitart J, Martinez-Escala ME, Subtil A, et al. Primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphomas: reappraisal of a provisional entity in the 2016 WHO classification of cutaneous lymphomas. Mod Pathol. 2017;30(5):761-772.
Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375-2390.
Martin B, Stefanato C, Whittaker S, Robson A. Primary cutaneous CD20-positive T- cell lymphoma. J Cutan Pathol. 2011;38(8):663-669.
Jullié ML, Carlotti M, Vivot Jr A, et al. CD20 antigen may be expressed by reactive or lymphomatous cells of transformed mycosis fungoides: diagnostic and prognostic impact. Am J Surg Pathol. 2013;37(12):1845-1854.
Hagen JW, Schaefer JT, Magro CM. CD20+ mycosis fungoides: a report of three cases and review of the literature. Am J Dermatopathol. 2013;35(8):833-841.

Keywords: CCNU; World Health Organization; chemotherapy; dog; lomustine; mycosis fungoides

Date Created: 20210712 Date Completed: 20220331 Latest Revision: 20220331

20240513

10.1111/vco.12752

34250731