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Quinolizidine-Based Variations and Antifungal Activity of Eight Lupinus Species Grown under Greenhouse Conditions.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, c1995-
    • Subject Terms:
      Antifungal Agents/*pharmacology ; Lupinus/*chemistry ; Plant Extracts/*pharmacology ; Quinolizidines/*pharmacology; Antifungal Agents/chemistry ; Gas Chromatography-Mass Spectrometry ; Greenhouse Effect ; Lupinus/growth & development ; Microbial Sensitivity Tests ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Plant Extracts/chemistry ; Quinolizidines/chemistry
    • Abstract:
      Fusarium oxysporum is an aggressive phytopathogen that affects various plant species, resulting in extensive local and global economic losses. Therefore, the search for competent alternatives is a constant pursuit. Quinolizidine alkaloids (QA) are naturally occurring compounds with diverse biological activities. The structural diversity of quinolizidines is mainly contributed by species of the family Fabaceae, particularly the genus Lupinus . This quinolizidine-based chemo diversity can be explored to find antifungals and even mixtures to address concomitant effects on F. oxysporum. Thus, the antifungal activity of quinolizidine-rich extracts (QREs) from the leaves of eight greenhouse-propagated Lupinus species was evaluated to outline promising QA mixtures against F. oxysporum. Thirteen main compounds were identified and quantified using an external standard. Quantitative analysis revealed different contents per quinolizidine depending on the Lupinus plant, ranging from 0.003 to 32.8 mg/g fresh leaves. Bioautography showed that all extracts were active at the maximum concentration (5 µg/µL). They also exhibited >50% mycelium growth inhibition. All QREs were fungistatic except for the fungicidal QRE of L. polyphyllus Lindl. Angustifoline, matrine, 13α-hydroxylupanine, and 17-oxolupanine were ranked to act jointly against the phytopathogen. Our findings constitute reference information to better understand the antifungal activity of naturally afforded QA mixtures from these globally important plants.
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    • Grant Information:
      IMP-CIAS-2924 Military University Nueva Granada
    • Contributed Indexing:
      Keywords: Fabaceae; Fusarium oxysporum; Lupinus; alkaloids; antifungals; quinolizidines
    • Accession Number:
      0 (Antifungal Agents)
      0 (Phytochemicals)
      0 (Plant Extracts)
      0 (Quinolizidines)
    • Publication Date:
      Date Created: 20220111 Date Completed: 20220208 Latest Revision: 20220208
    • Publication Date:
      20240513
    • Accession Number:
      PMC8746871
    • Accession Number:
      10.3390/molecules27010305
    • Accession Number:
      35011535