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The preparation and characterisation of tasteless core-shell clarithromycin microcapsules.

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  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 8500513 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-5246 (Electronic) Linking ISSN: 02652048 NLM ISO Abbreviation: J Microencapsul Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: London [England] ; Philadelphia : Taylor & Francis, c1984-
    • Subject Terms:
      Clarithromycin* ; Polymers*/chemistry; Spectroscopy, Fourier Transform Infrared ; Capsules/chemistry ; Drug Compounding ; Water/chemistry
    • Abstract:
      This study aims to fabricate core-shell clarithromycin (CAM) microcapsules to cover up the bitter taste of CAM by spray drying with aqueous polymer dispersion. Water dispersion of Eudragit EPO and Surelease ® were innovatively used to encapsulate CAM into microcapsules via a one-step spray-drying method. The inlet air temperature, airflow rate, CAM-polymer ratio, and particle size of CAM were optimised based on drug content and T 6% (the time taken for the drug to release equal to 6% w / w ). The powder properties were assessed by measuring particle size and microstructure using SEM, FT-IR, and PXRD. Furthermore, selected batch was assessed for their drug content, encapsulation efficiency, in vitro release, bitterness, and stability studies. EPO-Surelease ® (1: 4) microcapsules had an average diameter (D50) of 37.69 ± 3.61 μm with a span of 2.395. The drug contents and encapsulation efficiency of EPO-Surelease ® (1:4) were 10.89% and 63.7%, respectively. EPO-Surelease ® (1:4) microcapsules prepared by spray drying with aqueous polymer dispersion can effectively mask the bitter taste of CAM.
    • Contributed Indexing:
      Keywords: Tasteless; aqueous polymer dispersion; clarithromycin; microcapsules; spray drying
    • Accession Number:
      H1250JIK0A (Clarithromycin)
      0 (Capsules)
      0 (Polymers)
      059QF0KO0R (Water)
    • Publication Date:
      Date Created: 20221208 Date Completed: 20230113 Latest Revision: 20230113
    • Publication Date:
      20250114
    • Accession Number:
      10.1080/02652048.2022.2146221
    • Accession Number:
      36476313