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Orange juice intake and lipid profile: a systematic review and meta-analysis of randomised controlled trials.

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  • Additional Information
    • Source:
      Publisher: Cambridge University Press Country of Publication: England NLM ID: 101590587 Publication Model: eCollection Cited Medium: Internet ISSN: 2048-6790 (Electronic) Linking ISSN: 20486790 NLM ISO Abbreviation: J Nutr Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Cambridge : Cambridge University Press, 2012-
    • Subject Terms:
      Citrus sinensis* ; Dyslipidemias*; Cholesterol, LDL ; Lipids ; Flavonoids ; Randomized Controlled Trials as Topic
    • Abstract:
      Dyslipidaemia is a metabolic anomaly which has been related to numerous morbidities. Orange juice (OJ) is a popular flavonoid-rich drink consumed worldwide. Due to the existing controversies regarding its impact on blood lipids, we decided to investigate the impact of OJ supplementation on lipid profile parameters. Major scientific databases (Cochrane library, Scopus, PubMed and Embase) were searched. Pooled effects sizes were reported as weighted mean difference (WMD) and 95 % confidence intervals (CIs). Out of 6334 articles retrieved by the initial search, 9 articles met our inclusion criteria. Overall, supplementation with OJ did not exert any significant effects on blood levels of TG (WMD -1·53 mg/dl, 95 % CI -6·39, 3·32, P = 0·536), TC (WMD -5·91 mg/dl, 95 % CI -13·26, 1·43, P = 0·114) or HDL-C (WMD 0·61 mg/ dl, 95 % CI -0·61, 1·82, P = 0·333). OJ consumption did reduce LDL-C levels significantly (WMD -8·35 mg/dl, 95 % CI -15·43, -1·26, P = 0·021). Overall, we showed that the consumption of OJ may not be beneficial in improving serum levels of TG, TC or HDL-C. Contrarily, we showed that daily intake of OJ, especially more than 500 ml/d, might be effective in reducing LDL-C levels. In the light of the existing inconsistencies, we propose that further high-quality interventions be conducted in order to make a solid conclusion.
      (© The Author(s) 2023.)
    • References:
      Clin Nutr. 2003 Dec;22(6):561-8. (PMID: 14613759)
      Nutr J. 2012 Dec 12;11:107. (PMID: 23234248)
      PLoS Med. 2009 Jul 21;6(7):e1000097. (PMID: 19621072)
      Molecules. 2007 Aug 03;12(8):1641-73. (PMID: 17960080)
      Phytother Res. 2019 Mar;33(3):534-545. (PMID: 30632207)
      ISRN Nutr. 2014 Mar 04;2014:405867. (PMID: 24967267)
      Lipids. 1999 Jun;34(6):591-8. (PMID: 10405973)
      BMC Med Res Methodol. 2005 Apr 20;5:13. (PMID: 15840177)
      J Agric Food Chem. 2004 May 19;52(10):2879-86. (PMID: 15137829)
      BMJ. 1997 Sep 13;315(7109):629-34. (PMID: 9310563)
      Adv Nutr. 2022 Feb 1;13(1):116-137. (PMID: 34634114)
      Pharmaceuticals (Basel). 2019 Jan 10;12(1):. (PMID: 30634637)
      Crit Rev Food Sci Nutr. 2022;62(30):8335-8354. (PMID: 34014143)
      BMJ. 2015 Jul 21;351:h3576. (PMID: 26199070)
      Lancet Planet Health. 2019 Jul;3(7):e318-e329. (PMID: 31326072)
      Circulation. 2002 Dec 17;106(25):3143-421. (PMID: 12485966)
      Nutr Res. 2010 Oct;30(10):689-94. (PMID: 21056284)
      Int J Mol Sci. 2017 Mar 04;18(3):. (PMID: 28273863)
      Nutrition. 2017 Jun;38:13-19. (PMID: 28526377)
      Eur J Clin Nutr. 2023 Feb 3;:. (PMID: 36737479)
      Nutr Rev. 2019 Dec 1;77(12):845-864. (PMID: 31271436)
      Life Sci. 2006 Jun 20;79(4):365-73. (PMID: 16497336)
      J Nutr. 2015 Aug;145(8):1808-16. (PMID: 26136593)
      Maturitas. 2010 Dec;67(4):343-7. (PMID: 20729016)
      Lipids Health Dis. 2013 Aug 06;12:119. (PMID: 23919812)
      Crit Rev Food Sci Nutr. 2017 Jun 13;57(9):1950-1962. (PMID: 26192884)
      J Nutr Biochem. 2022 Jun;104:108967. (PMID: 35189328)
      Am J Clin Nutr. 2011 Jan;93(1):73-80. (PMID: 21068346)
      Food Nutr Res. 2017 Mar 22;61(1):1296675. (PMID: 28469541)
      Am J Clin Nutr. 2008 Jul;88(1):38-50. (PMID: 18614722)
      Eur J Clin Nutr. 2003 Feb;57(2):235-42. (PMID: 12571654)
      Curr Opin Lipidol. 2013 Feb;24(1):34-40. (PMID: 23254473)
      Biosci Biotechnol Biochem. 1997 Jan;61(1):102-4. (PMID: 9028038)
      Biomed Pharmacother. 2022 Oct;154:113563. (PMID: 35987162)
      J Nutr. 1999 Jun;129(6):1182-5. (PMID: 10356084)
      BMJ. 2011 Oct 18;343:d5928. (PMID: 22008217)
      Nutrients. 2019 Feb 05;11(2):. (PMID: 30764511)
      J Agric Food Chem. 2001 Feb;49(2):1035-41. (PMID: 11262068)
      Food Funct. 2016 Apr;7(4):1884-91. (PMID: 26965492)
      Endocr Pract. 2020 Oct;26(10):1196-1224. (PMID: 33471721)
      Clin Nutr. 2015 Dec;34(6):1093-100. (PMID: 25865966)
    • Contributed Indexing:
      Keywords: Lipid profile; Meta-analysis; Orange juice; RCT
    • Accession Number:
      0 (Cholesterol, LDL)
      0 (Lipids)
      0 (Flavonoids)
    • Publication Date:
      Date Created: 20230403 Date Completed: 20230404 Latest Revision: 20230610
    • Publication Date:
      20250114
    • Accession Number:
      PMC10052563
    • Accession Number:
      10.1017/jns.2023.22
    • Accession Number:
      37008412