The role of lysosomal membrane proteins in autophagy and related diseases.

Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE

Original Publication: Oxford, UK : Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies, c2005-

Autophagy*/genetics ; Lysosomes*/metabolism ; Neurodegenerative Diseases*/metabolism ; Neurodegenerative Diseases*/genetics ; Neurodegenerative Diseases*/pathology ; Lysosomal Membrane Proteins*/metabolism ; Lysosomal Membrane Proteins*/genetics; Humans ; Animals ; Neoplasms/metabolism ; Neoplasms/genetics ; Neoplasms/pathology ; Autophagosomes/metabolism

As a self-degrading and highly conserved survival mechanism, autophagy plays an important role in maintaining cell survival and recycling. The discovery of autophagy-related (ATG) genes has revolutionized our understanding of autophagy. Lysosomal membrane proteins (LMPs) are important executors of lysosomal function, and increasing evidence has demonstrated their role in the induction and regulation of autophagy. In addition, the functional dysregulation of the process mediated by LMPs at all stages of autophagy is closely related to neurodegenerative diseases and cancer. Here, we review the role of LMPs in autophagy, focusing on their roles in vesicle nucleation, vesicle elongation and completion, the fusion of autophagosomes and lysosomes, and degradation, as well as their broad association with related diseases.
(© 2023 Federation of European Biochemical Societies.)

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81471002 National Natural Science Foundation of China; 81800766 National Natural Science Foundation of China; 2108085MH267 Natural Science Foundation of Anhui Province; PF2019013 'Climbing Peak' Training Program for Innovative Technology team of Yijishan Hospital; GF2019J07 'Peak' Training Program for Scientific Research of Yijishan Hospital; S202010368117 Anhui Province College Students' Innovation and Entrepreneurship Training Programme Project; WK2022XS50 Wannan Medical College Scientific Research Grant Program for university students

Keywords: autophagy; autophagy‐related gene; disease; lysosomal membrane protein; lysosome

0 (Lysosomal Membrane Proteins)

Date Created: 20230524 Date Completed: 20241009 Latest Revision: 20241009

20250114

10.1111/febs.16820

37221945