Exploring the Genetic Diversity of Epstein-Barr Virus among Patients with Gastric Cancer in Southern Chile.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Stomach Neoplasms*/epidemiology ; Stomach Neoplasms*/genetics ; Stomach Neoplasms*/pathology ; Epstein-Barr Virus Infections*/complications ; Epstein-Barr Virus Infections*/epidemiology; Humans ; Herpesvirus 4, Human/genetics ; Chile/epidemiology ; Phylogeny ; Genetic Variation

The Epstein-Barr virus (EBV) has been associated with gastric cancer (GC), one of the deadliest malignancies in Chile and the world. Little is known about Chilean EBV strains. This study aims to investigate the frequency and genetic diversity of EBV in GC in patients in southern Chile. To evaluate the prevalence of EBV in GC patients from the Chilean population, we studied 54 GC samples using the gold standard detection method of EBV-encoded small RNA (EBER). The EBV-positive samples were subjected to amplification and sequencing of the Epstein-Barr virus nuclear protein 3A ( EBNA3A ) gene to evaluate the genetic diversity of EBV strains circulating in southern Chile. In total, 22.2% of the GC samples were EBV-positive and significantly associated with diffuse-type histology ( p = 0.003). Phylogenetic analyses identified EBV-1 and EBV-2 in the GC samples, showing genetic diversity among Chilean isolates. This work provides important information for an epidemiological follow-up of the different EBV subtypes that may cause GC in southern Chile.

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825510 International ERC_ European Research Council

Keywords: Chile; EBNA3A; Epstein–Barr virus (EBV); gastric cancer; phylogeny

Date Created: 20230729 Date Completed: 20230731 Latest Revision: 20230801

20231215

PMC10378801

10.3390/ijms241411276

37511034