Emerging Roles of Lysophosphatidic Acid in Macrophages and Inflammatory Diseases.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Receptors, Lysophosphatidic Acid* ; Lysophospholipids*; Humans ; Macrophages ; Inflammation

Lysophosphatidic acid (LPA) is a bioactive phospholipid that regulates physiological and pathological processes in numerous cell biological functions, including cell migration, apoptosis, and proliferation. Macrophages are found in most human tissues and have multiple physiological and pathological functions. There is growing evidence that LPA signaling plays a significant role in the physiological function of macrophages and accelerates the development of diseases caused by macrophage dysfunction and inflammation, such as inflammation-related diseases, cancer, atherosclerosis, and fibrosis. In this review, we summarize the roles of LPA in macrophages, analyze numerous macrophage- and inflammation-associated diseases triggered by LPA, and discuss LPA-targeting therapeutic strategies.

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92057119 National Natural Science Foundation of China; 23ZR1408200 Shanghai Natural Science Foundation; 22YF1404000 Shanghai Sailing Program; JIF157602 Program for Zhuoxue of Fudan University; DGF828013/032 Training Program for Famous Medical Teachers of Fudan University

Keywords: atherosclerosis; fibrosis; inflammation; lysophosphatidic acid; lysophosphatidic acid receptor; macrophage

PG6M3969SG (lysophosphatidic acid)
0 (Receptors, Lysophosphatidic Acid)
0 (Lysophospholipids)

Date Created: 20230812 Date Completed: 20230814 Latest Revision: 20230814

20250114

PMC10419859

10.3390/ijms241512524

37569902