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Anaemia and iron deficiency associate with polymorphism TMPRSS6 rs855791 in Brazilian children attending day care centres.

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  • Additional Information
    • Source:
      Publisher: Published on behalf of the Nutrition Society by CABI Publishing Country of Publication: England NLM ID: 0372547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-2662 (Electronic) Linking ISSN: 00071145 NLM ISO Abbreviation: Br J Nutr Subsets: MEDLINE
    • Publication Information:
      Publication: <2000->: Wallingford, Oxon, UK : Published on behalf of the Nutrition Society by CABI Publishing
      Original Publication: [Cambridge, New York] Cambridge University Press.
    • Subject Terms:
      Anemia*/epidemiology ; Anemia*/genetics ; Anemia, Iron-Deficiency*/epidemiology ; Anemia, Iron-Deficiency*/genetics ; Iron Deficiencies*; Child, Preschool ; Humans ; Brazil/epidemiology ; Cross-Sectional Studies ; Day Care, Medical ; Membrane Proteins/genetics ; Polymorphism, Single Nucleotide ; Receptors, Transferrin ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism
    • Abstract:
      Fe-deficiency anaemia is a major public health concern in children under 5 years of age. TMPRSS6 gene, encoding matriptase-2 protein, is implicated in Fe homoeostasis and has been associated with anaemia and Fe status in various populations. The aim of this cross-sectional study was to investigate the associations between the single nucleotide polymorphism (SNP) TMPRSS6 rs855791 and biomarkers of anaemia and Fe deficiency in Brazilian children attending day care centres. A total of 163 children aged 6-42 months were evaluated. Socio-economic, demographic, biochemical, haematological, immunological and genotype data were collected. Multiple logistic and linear regressions with hierarchical selection were used to assess the effects of independent variables on categorised outcomes and blood marker concentrations. Minor allele (T) frequency of rs855791 was 0·399. Each copy of the T allele was associated with a 4·49-fold increased risk of developing anaemia ( P = 0·005) and a 4·23-fold increased risk of Fe deficiency assessed by serum soluble transferrin receptor (sTfR) ( P < 0·001). The dose of the T allele was associated with an increase of 0·18 mg/l in sTfR concentrations and reductions of 1·41 fl and 0·52 pg in mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH), respectively. In conclusion, the T allele of SNP TMPRSS6 rs855791 was significantly associated with anaemia and Fe deficiency assessed by sTfR in Brazilian children attending day care centres. The effect was dose dependent, with each copy of the T allele being associated with lower MCV and MCH and higher concentrations of sTfR.
    • Contributed Indexing:
      Keywords: Blood cell counts; Genetic polymorphism; Infant; Matriptase-2; Transferrin receptor
    • Accession Number:
      0 (Membrane Proteins)
      0 (Receptors, Transferrin)
      EC 3.4.21.- (Serine Endopeptidases)
      EC 3.4.21.- (TMPRSS6 protein, human)
    • Publication Date:
      Date Created: 20230822 Date Completed: 20240111 Latest Revision: 20240306
    • Publication Date:
      20240306
    • Accession Number:
      10.1017/S0007114523001848
    • Accession Number:
      37605822