Investigations into the characterization, degradation, and applications of biodegradable polymers by mass spectrometry.

Publisher: Wiley Country of Publication: United States NLM ID: 8219702 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2787 (Electronic) Linking ISSN: 02777037 NLM ISO Abbreviation: Mass Spectrom Rev Subsets: MEDLINE

Original Publication: New York : Wiley, [c1982-

Mass Spectrometry*/methods ; Biodegradable Plastics*/chemistry ; Biodegradable Plastics*/analysis ; Biodegradable Plastics*/metabolism ; Polymers*/chemistry; Humans ; Polymerization ; Biodegradation, Environmental

Biodegradable polymers have been getting more and more attention because of their contribution to the plastic pollution environmental issues and to move towards a circular economy. Nevertheless, biodegradable materials still exhibit various disadvantages restraining a widespread use in the market. Therefore, additional research efforts are required to improve their performance. Mass spectrometry (MS) affords a relevant contribution to optimize biodegradable polymer synthesis, to confirm macromolecular structures, to examine along the time the progress of degradation processes and highlight advantages and drawbacks in the extensive applications. This review aims to provide an overview of the MS investigations carried out to support the synthesis of biodegradable polymers, with helpful information on undesirable products or polymerization mechanism, to understand deterioration pathways by the structure of degradation products and to follow drug release and pharmacokinetic. Additionally, it summarizes MS studies addressed on environmental and health issues related to the extensive use of plastic materials, that is, potential migration of additives or microplastics identification and quantification. The paper is focused on the most significant studies relating to synthetic and microbial biodegradable polymers published in the last 15 years, not including agro-polymers such as proteins and polysaccharides.
(© 2023 The Authors. Mass Spectrometry Reviews published by John Wiley & Sons Ltd.)

Acta Pharm Sin B. 2022 Jul;12(7):3156-3166. (PMID: 35865103)
Sci Rep. 2020 Jun 1;10(1):8815. (PMID: 32483188)
Appl Surf Sci. 2008 Dec 15;255(4):1170-1173. (PMID: 20016666)
BMC Microbiol. 2022 Jul 22;22(1):183. (PMID: 35869433)
J Biomater Sci Polym Ed. 2018 Dec;29(17):2124-2136. (PMID: 30157706)
J Ind Microbiol Biotechnol. 2010 Aug;37(8):849-56. (PMID: 20467780)
Polymers (Basel). 2022 Jul 12;14(14):. (PMID: 35890616)
Acta Biomater. 2015 May;18:68-76. (PMID: 25707922)
Acta Biomater. 2014 May;10(5):2096-104. (PMID: 24365706)
Eur J Pharm Biopharm. 2012 Apr;80(3):562-70. (PMID: 22209978)
Water Res. 2021 Jun 15;198:117123. (PMID: 33865028)
J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Sep 1;1125:121716. (PMID: 31319286)
J Am Chem Soc. 2017 May 3;139(17):6177-6182. (PMID: 28397499)
Molecules. 2018 Aug 14;23(8):. (PMID: 30110952)
Bioconjug Chem. 2017 Aug 16;28(8):2190-2198. (PMID: 28661654)
Acta Biomater. 2017 Apr 15;53:222-232. (PMID: 28216296)
Biomacromolecules. 2008 Mar;9(3):949-53. (PMID: 18271512)
Prep Biochem Biotechnol. 2014;44(8):822-33. (PMID: 24279753)
Environ Sci Technol. 2022 Feb 15;56(4):2398-2406. (PMID: 35119274)
Rapid Commun Mass Spectrom. 2020 Aug;34 Suppl 2:e8624. (PMID: 31658387)
PLoS Biol. 2021 Mar 30;19(3):e3001130. (PMID: 33784293)
Int J Mol Sci. 2009 Aug 17;10(8):3599-3615. (PMID: 19812715)
Anal Chim Acta. 2016 Aug 17;932:1-21. (PMID: 27286765)
Biomacromolecules. 2021 May 10;22(5):1932-1943. (PMID: 33830737)
Anal Bioanal Chem. 2021 Aug;413(20):5121-5133. (PMID: 34184103)
Sci Total Environ. 2016 Oct 1;566-567:27-33. (PMID: 27213667)
Acta Biomater. 2012 May;8(5):1859-68. (PMID: 22281944)
Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:470-81. (PMID: 25492012)
J Mass Spectrom. 2009 Sep;44(9):1277-86. (PMID: 19676098)
Chemosphere. 2022 Sep;303(Pt 1):134946. (PMID: 35569634)
Anal Bioanal Chem. 2011 Jan;399(3):1163-72. (PMID: 21107817)
Polymers (Basel). 2023 May 18;15(10):. (PMID: 37242931)
J Hazard Mater. 2023 Jan 5;441:129958. (PMID: 36122523)
Mater Sci Eng C Mater Biol Appl. 2014 May 1;38:85-93. (PMID: 24656356)
Drug Deliv. 2019 Dec;26(1):290-299. (PMID: 30895841)
Water Res. 2008 Dec;42(19):4791-801. (PMID: 18823927)
Mass Spectrom Rev. 2024 May-Jun;43(3):427-476. (PMID: 37070280)
N Biotechnol. 2016 Mar 25;33(2):295-304. (PMID: 26594021)
Int J Biol Macromol. 2022 Jul 31;213:728-737. (PMID: 35671908)
Front Microbiol. 2021 Oct 15;12:711588. (PMID: 34721317)
Chemosphere. 2020 Nov;259:127472. (PMID: 32599378)
J Environ Sci (China). 2021 May;103:50-58. (PMID: 33743918)
Molecules. 2018 Sep 05;23(9):. (PMID: 30189595)
Biomacromolecules. 2016 Oct 10;17(10):3338-3346. (PMID: 27618845)
Sci Total Environ. 2021 Aug 1;780:146546. (PMID: 33770602)
Waste Manag. 2018 Aug;78:938-947. (PMID: 32559989)
Biomacromolecules. 2014 Nov 10;15(11):4168-77. (PMID: 25296397)
Environ Sci Technol. 2022 Nov 15;56(22):15746-15759. (PMID: 36301071)
J Mass Spectrom. 2012 Nov;47(11):1442-9. (PMID: 23147820)
Rapid Commun Mass Spectrom. 2012 Dec 15;26(23):2673-82. (PMID: 23124657)
Mol Pharm. 2012 Nov 5;9(11):3200-8. (PMID: 22954154)
Bioconjug Chem. 2008 May;19(5):1071-7. (PMID: 18447367)
Biomacromolecules. 2019 Jan 14;20(1):141-148. (PMID: 30395450)
Nat Commun. 2019 Jun 12;10(1):2566. (PMID: 31189915)
Eur J Pharm Sci. 2014 Oct 1;62:49-56. (PMID: 24859314)
Molecules. 2021 Aug 11;26(16):. (PMID: 34443448)
PLoS One. 2017 Aug 10;12(8):e0182929. (PMID: 28797120)
J Pharm Sci. 2010 Aug;99(8):3381-8. (PMID: 20213838)
Sci Total Environ. 2020 Oct 1;737:139716. (PMID: 32526568)
Rapid Commun Mass Spectrom. 2008;22(6):739-54. (PMID: 18278818)
Waste Manag. 2021 May 15;127:101-111. (PMID: 33932851)
J Mater Sci Mater Med. 2018 Nov 30;29(12):177. (PMID: 30506149)
Mass Spectrom Rev. 2016 Jan-Feb;35(1):188-98. (PMID: 25869251)
ACS Appl Bio Mater. 2022 Aug 15;5(8):3972-3981. (PMID: 35905450)
Rapid Commun Mass Spectrom. 2013 Apr 15;27(7):773-83. (PMID: 23495024)
Biotechnol J. 2010 Nov;5(11):1181-5. (PMID: 20949541)
ACS Appl Bio Mater. 2019 Jul 15;2(7):3038-3051. (PMID: 35030796)
J Pharm Sci. 2008 Jan;97(1):506-18. (PMID: 17879976)
ACS Nano. 2021 Mar 23;15(3):5428-5438. (PMID: 33689300)
Int J Nanomedicine. 2014 Mar 26;9:1463-77. (PMID: 24741303)
Acta Biomater. 2011 Oct;7(10):3708-18. (PMID: 21672641)
J Control Release. 2012 Jul 10;161(1):81-9. (PMID: 22561340)
Sci Total Environ. 2021 Jan 1;750:141228. (PMID: 32871365)
Anal Chim Acta. 2019 Feb 7;1048:85-95. (PMID: 30598161)
Rapid Commun Mass Spectrom. 2011 May 15;25(9):1152-8. (PMID: 21488114)
Pharm Res. 2010 Feb;27(2):272-84. (PMID: 19998055)
Int J Pharm. 2021 May 15;601:120527. (PMID: 33781881)
Foods. 2020 Jan 09;9(1):. (PMID: 31936455)
Int J Biol Macromol. 2018 Mar;108:608-614. (PMID: 29223758)
Microb Cell Fact. 2017 Aug 17;16(1):144. (PMID: 28818103)
Int J Pharm. 2020 May 15;581:119291. (PMID: 32259638)
Nat Commun. 2019 Sep 20;10(1):4324. (PMID: 31541085)
Bioact Mater. 2020 Sep 21;6(3):655-665. (PMID: 33005829)
Sci Adv. 2018 Jul 25;4(7):eaas9024. (PMID: 30050987)
Molecules. 2015 Feb 09;20(2):2816-27. (PMID: 25690282)
Anal Chem. 2022 Aug 30;94(34):11734-11738. (PMID: 35977070)
ACS Chem Biol. 2021 Jul 16;16(7):1215-1222. (PMID: 34143620)
Rapid Commun Mass Spectrom. 2009 Nov;23(21):3409-22. (PMID: 19810122)
Biomacromolecules. 2008 Jan;9(1):36-42. (PMID: 18047289)
Environ Sci Technol. 2019 Mar 5;53(5):2472-2481. (PMID: 30726677)
Int J Biol Macromol. 2019 May 1;128:825-838. (PMID: 30690115)
Bioresour Technol. 2018 Apr;253:333-342. (PMID: 29413997)
Acta Biomater. 2010 Nov;6(11):4189-98. (PMID: 20561601)
Environ Sci Technol. 2022 Sep 20;56(18):13029-13035. (PMID: 36055676)
Nanomedicine. 2012 Nov;8(8):1293-300. (PMID: 22321382)
Sci Total Environ. 2022 Jul 20;831:154840. (PMID: 35367264)
Polymers (Basel). 2022 Apr 07;14(8):. (PMID: 35458250)
Rapid Commun Mass Spectrom. 2009 Sep;23(17):2768-74. (PMID: 19639583)
Biomacromolecules. 2016 Jun 13;17(6):2027-39. (PMID: 27087107)
Int J Cardiol. 2014 Jul 1;174(3):688-95. (PMID: 24820736)
Chem Sci. 2020 Feb 27;11(12):3345-3354. (PMID: 34122842)
Materials (Basel). 2020 May 11;13(9):. (PMID: 32403315)
Biomaterials. 2014 Aug;35(25):7088-100. (PMID: 24840615)
Biomaterials. 2011 Oct;32(30):7732-9. (PMID: 21783244)
Macromol Rapid Commun. 2021 Apr;42(8):e2000752. (PMID: 33629782)
Adv Healthc Mater. 2022 Apr;11(7):e2101544. (PMID: 34706167)
Materials (Basel). 2016 May 13;9(5):. (PMID: 28773492)
Adv Healthc Mater. 2022 May;11(9):e2100894. (PMID: 34347389)
Polymers (Basel). 2018 Aug 29;10(9):. (PMID: 30960882)
Polymers (Basel). 2021 Dec 04;13(23):. (PMID: 34883760)
J Biomed Mater Res A. 2009 Nov;91(2):454-62. (PMID: 18985760)
Rapid Commun Mass Spectrom. 2018 Mar 15;32(5):423-430. (PMID: 29235689)
Biomacromolecules. 2018 May 14;19(5):1498-1507. (PMID: 29554423)
Bioengineering (Basel). 2017 Aug 28;4(3):. (PMID: 28952552)
Environ Sci Technol. 2014 Nov 4;48(21):12783-90. (PMID: 25296394)
Pharmaceutics. 2020 May 30;12(6):. (PMID: 32486203)
Biointerphases. 2018 Jan 10;13(3):03B401. (PMID: 29320860)
Environ Sci Pollut Res Int. 2021 Dec;28(47):66511-66518. (PMID: 34532795)
Anal Chim Acta. 2018 Apr 3;1004:58-66. (PMID: 29329709)
J Am Chem Soc. 2015 Jul 8;137(26):8324-7. (PMID: 26086212)
Angew Chem Int Ed Engl. 2017 Feb 1;56(6):1452-1464. (PMID: 27712048)
World J Microbiol Biotechnol. 2015 Oct;31(10):1555-63. (PMID: 26187125)
Mol Pharm. 2020 Jan 6;17(1):59-69. (PMID: 31751144)
Anal Chem. 2011 Feb 1;83(3):654-60. (PMID: 21204561)
Mass Spectrom Rev. 2025 Nov-Dec;44(6):947-988. (PMID: 38014928)
Int J Biol Macromol. 2018 Feb;107(Pt B):2157-2170. (PMID: 29054518)
Rapid Commun Mass Spectrom. 2020 Aug;34 Suppl 2:e8697. (PMID: 31834664)
Materials (Basel). 2016 Apr 25;9(5):. (PMID: 28773432)
Chemosphere. 2017 Jun;176:47-56. (PMID: 28254714)
Molecules. 2022 Oct 29;27(21):. (PMID: 36364191)
Rapid Commun Mass Spectrom. 2013 Oct 15;27(19):2213-25. (PMID: 23996395)
Pharm Res. 2011 Jul;28(7):1668-82. (PMID: 21394661)
Cancer Chemother Pharmacol. 2009 Jul;64(2):287-95. (PMID: 19034451)
Rapid Commun Mass Spectrom. 2015 May 15;29(9):811-20. (PMID: 26377009)
Anal Bioanal Chem. 2017 Sep;409(23):5401-5411. (PMID: 28508925)
Eur J Mass Spectrom (Chichester). 2017 Dec;23(6):402-410. (PMID: 29183194)
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jul 15;870(2):247-50. (PMID: 18603487)
Rapid Commun Mass Spectrom. 2020 Mar 15;34(5):e8597. (PMID: 31520435)
Eur J Pharm Sci. 2015 Aug 30;76:1-9. (PMID: 25933716)
Int J Biol Macromol. 2011 Jan 1;48(1):137-45. (PMID: 21035502)
Sci Total Environ. 2022 Dec 1;850:158761. (PMID: 36154974)
Polymers (Basel). 2021 Nov 03;13(21):. (PMID: 34771358)
Polymers (Basel). 2019 Sep 27;11(10):. (PMID: 31569718)
Polymers (Basel). 2022 Mar 31;14(7):. (PMID: 35406308)
Biointerphases. 2020 Aug 04;15(4):041008. (PMID: 32752604)
Anal Chem. 2017 Jan 17;89(2):1170-1177. (PMID: 27936608)
Int J Pharm. 2008 Feb 4;348(1-2):95-106. (PMID: 17825508)
Molecules. 2022 Mar 15;27(6):. (PMID: 35335267)
Int J Mol Sci. 2021 Jul 28;22(15):. (PMID: 34360814)
Anal Chim Acta. 2014 Jan 15;808:18-43. (PMID: 24370091)
Pharmaceutics. 2020 Aug 02;12(8):. (PMID: 32748816)
Environ Sci Technol. 2022 Oct 4;56(19):13774-13785. (PMID: 36128767)
Talanta. 2016;146:107-13. (PMID: 26695241)
Waste Manag. 2016 Jun;52:69-76. (PMID: 27103398)
J Hazard Mater. 2022 Jul 5;433:128801. (PMID: 35405589)
Mass Spectrom Rev. 2011 Jul-Aug;30(4):523-59. (PMID: 20623599)
J Am Soc Mass Spectrom. 2020 Jul 1;31(7):1554-1562. (PMID: 32510219)
Biomed Mater. 2011 Jun;6(3):035004. (PMID: 21498894)
Environ Technol. 2013 Jan-Feb;34(1-4):149-55. (PMID: 23530325)
Rapid Commun Mass Spectrom. 2015 Mar 30;29(6):533-44. (PMID: 26160419)
Int J Mol Sci. 2014 Sep 22;15(9):16831-47. (PMID: 25247580)
ACS Appl Mater Interfaces. 2011 Jul;3(7):2487-95. (PMID: 21699231)
Chemosphere. 2023 Feb;313:137494. (PMID: 36513198)

G68I18000700007 PO FESR 2014-2020

Keywords: biodegradable polymers; characterization; degradation; drug release; microplastics; polyhydroxyalkanoates

0 (Biodegradable Plastics)
0 (Polymers)

Date Created: 20231128 Date Completed: 20251007 Latest Revision: 20251009

20260130

PMC12502033

10.1002/mas.21869

38014928