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Prenatal maternal cortisol, stress and anxiety, and childhood obesity at 5 years: a nested case-control study.

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  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 8501885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-672X (Electronic) Linking ISSN: 02646838 NLM ISO Abbreviation: J Reprod Infant Psychol Subsets: MEDLINE
    • Publication Information:
      Publication: Abingdon : Taylor & Francis
      Original Publication: Lincoln, England : Society for Reproductive and Infant Psychology, c1983-
    • Subject Terms:
      Pediatric Obesity*/epidemiology ; Pediatric Obesity*/etiology ; Hydrocortisone*/blood ; Anxiety*/epidemiology ; Anxiety*/blood ; Stress, Psychological*/blood ; Stress, Psychological*/epidemiology ; Prenatal Exposure Delayed Effects*/psychology ; Depression*/epidemiology ; Mothers*/psychology; Humans ; Female ; Case-Control Studies ; Pregnancy ; Male ; Child, Preschool ; Adult ; Prospective Studies ; Longitudinal Studies ; Ireland/epidemiology ; Body Mass Index ; Pregnancy Trimester, Second ; Pregnancy Complications
    • Abstract:
      Background: Paediatric obesity is a global public health issue. Prenatal maternal mental health is potentially implicated in the development of childhood obesity. This study examined associations between prenatal maternal cortisol, self-reported stress, anxiety and depression in the second trimester, and childhood overweight and obesity at 5 years of age.
      Methods: A nested case-control study was conducted using data from the Irish prospective longitudinal birth cohort SCOPE BASELINE. Cases were children with overweight or obesity, operationalised as having a BMI z-score above +2 standard deviations. Controls were children with a BMI z-score between -0.5 and 0.5 standard deviations at 5 years of age. Two to one matching by sex was conducted. Thirty-eight cases and 83 sex-matched controls were included. Maternal serum cortisol concentration and self-reported stress, anxiety and depression were measured at 15 ± 1 and 20 ± 1 weeks gestation. Conditional logistic regression analyses were conducted to examine associations between prenatal maternal cortisol and self-reported stress, anxiety and depression, and childhood overweight and obesity.
      Results: Despite some evidence for associations between anxiety and depression, and child BMI z-scores in univariate analyses, adjusted models indicated no associations between prenatal maternal stress (OR: 1.02, 95% CI: 0.94-1.12), anxiety (OR: 1.03, 95% CI: 0.97-1.09), depression (OR: 1.04, 95% CI: 0.91-1.19), or cortisol concentration (OR: 0.99, 95% CI: 0.99-1.00) and child BMI z-score.
      Conclusion: Our findings do not provide support for associations between foetal exposure during the second trimester of pregnancy and maternal cortisol, stress and anxiety, and childhood overweight or obesity at 5 years of age.
    • Contributed Indexing:
      Keywords: Childhood obesity; anxiety; cortisol; pregnancy; stress
    • Accession Number:
      WI4X0X7BPJ (Hydrocortisone)
    • Publication Date:
      Date Created: 20231129 Date Completed: 20250618 Latest Revision: 20250618
    • Publication Date:
      20250618
    • Accession Number:
      10.1080/02646838.2023.2288298
    • Accession Number:
      38018852