Gut-Brain Axis Deregulation and Its Possible Contribution to Neurodegenerative Disorders.

Publisher: Springer Country of Publication: United States NLM ID: 100929017 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-3524 (Electronic) Linking ISSN: 10298428 NLM ISO Abbreviation: Neurotox Res Subsets: MEDLINE

Publication: <2009-> : New York : Springer
Original Publication: [Amsterdam?] : Harwood Academic Publishers,

Amyotrophic Lateral Sclerosis* ; Gastrointestinal Microbiome*/physiology ; Neurodegenerative Diseases*/pathology ; Parkinson Disease*/pathology ; Huntington Disease*/pathology ; Alzheimer Disease*; Animals ; Humans ; Brain-Gut Axis ; Central Nervous System

The gut-brain axis is an essential communication pathway between the central nervous system (CNS) and the gastrointestinal tract. The human microbiota is composed of a diverse and abundant microbial community that compasses more than 100 trillion microorganisms that participate in relevant physiological functions such as host nutrient metabolism, structural integrity, maintenance of the gut mucosal barrier, and immunomodulation. Recent evidence in animal models has been instrumental in demonstrating the possible role of the microbiota in neurodevelopment, neuroinflammation, and behavior. Furthermore, clinical studies suggested that adverse changes in the microbiota can be considered a susceptibility factor for neurological disorders (NDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS). In this review, we will discuss evidence describing the role of gut microbes in health and disease as a relevant risk factor in the pathogenesis of neurodegenerative disorders, including AD, PD, HD, and ALS.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

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1200178 Agencia Nacional de Investigación y Desarrollo

Keywords: Alzheimer’s disease; Amyotrophic lateral sclerosis; Gut-brain axis; Huntington’s disease; Microbiota; Parkinson’s disease

Date Created: 20231216 Date Completed: 20231218 Latest Revision: 20240227

20250114

10.1007/s12640-023-00681-0

38103074