Associations between healthy lifestyle and mortality across different social environments: a study among adults with frailty from the UK Biobank.

Publisher: Oxford University Press Country of Publication: England NLM ID: 9204966 Publication Model: Print Cited Medium: Internet ISSN: 1464-360X (Electronic) Linking ISSN: 11011262 NLM ISO Abbreviation: Eur J Public Health Subsets: MEDLINE

Publication: Oxford : Oxford University Press
Original Publication: Stockholm, Sweden : Almqvist & Wiksell International, c1991-

Frailty*; Adult ; Humans ; Biological Specimen Banks ; UK Biobank ; Healthy Lifestyle ; Life Style ; Social Environment ; Risk Factors

Background: Among people living with frailty, adherence to a healthy lifestyle may be a low-cost and effective strategy to decrease frailty-induced health risks across different social environments.
Methods: We included 15 594 frail participants at baseline from the UK Biobank study. We used four lifestyle factors to create a composite healthy lifestyle score and 17 social factors to construct a polysocial score. We classified the lifestyle score into two levels (unhealthy and healthy) and the polysocial score into three levels (low, intermediate and high). We used Cox regression to determine the association of each lifestyle factor and lifestyle score with all-cause mortality, respectively. We also examined the associations across polysocial score categories. We evaluated the joint association of the lifestyle score and the categorical polysocial score with all-cause mortality.
Results: During up to 14.41 follow-up years, we documented 3098 all-cause deaths. After multivariable adjustment, we found a significant association between not smoking and adequate physical activity with all-cause mortality across polysocial score categories, respectively. We also found a significant association between a healthy diet and all-cause mortality among frail participants living in an intermediate social environment. A healthy lifestyle was associated with a lower all-cause mortality risk across polysocial score categories, especially among those with a low polysocial score.
Conclusions: Adherence to a healthy lifestyle, particularly not smoking, adequate physical activity and a healthy diet, may provide a feasible solution to decreasing mortality risk among frail adults across different social environments, especially for those in the socially disadvantaged group.
(© The Author(s) 2024. Published by Oxford University Press on behalf of the European Public Health Association.)

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22KJB320010 Jiangsu Provincial Department of Education; WHUDKUZZJJ202206 Wuhan University

Date Created: 20240130 Date Completed: 20240405 Latest Revision: 20240405

20240405

PMC10990525

10.1093/eurpub/ckae003

38288504