Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Protein homeostasis and degradation in quiescent neural stem cells.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Author(s): Kobayashi T;Kobayashi T
  • Source:
    Journal of biochemistry [J Biochem] 2024 Apr 29; Vol. 175 (5), pp. 481-486.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 0376600 Publication Model: Print Cited Medium: Internet ISSN: 1756-2651 (Electronic) Linking ISSN: 0021924X NLM ISO Abbreviation: J Biochem Subsets: MEDLINE
    • Publication Information:
      Publication: : Abingdon, UK : Oxford University Press
      Original Publication: Tokyo : Japanese Biochemical Society
    • Subject Terms:
      Neural Stem Cells*/metabolism ; Neural Stem Cells*/cytology ; Proteolysis* ; Proteostasis*; Humans ; Animals ; Homeostasis ; Cell Differentiation
    • Abstract:
      Tissue stem cells are maintained in the adult body throughout life and are crucial for tissue homeostasis as they supply newly functional cells. Quiescence is a reversible arrest in the G0/G1 phase of the cell cycle and a strategy to maintain the quality of tissue stem cells. Quiescence maintains stem cells in a self-renewable and differentiable state for a prolonged period by suppressing energy consumption and cell damage and depletion. Most adult neural stem cells in the brain maintain the quiescent state and produce neurons and glial cells through differentiation after activating from the quiescent state to the proliferating state. In this process, proteostasis, including proteolysis, is essential to transition between the quiescent and proliferating states associated with proteome remodeling. Recent reports have demonstrated that quiescent and proliferating neural stem cells have different expression patterns and roles as proteostatic molecules and are affected by age, indicating differing processes for protein homeostasis in these two states in the brain. This review discusses the multiple regulatory stages from protein synthesis (protein birth) to proteolysis (protein death) in quiescent neural stem cells.
      (© The Author(s) 2024. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.)
    • Grant Information:
      JP20gm6410006 AMED PRIME; JSPS 23H04919 Grant-in-Aid for Transformative Research Areas
    • Contributed Indexing:
      Keywords: adult mouse brain; lysosomes; neural stem cells; proteostasis; quiescence
    • Publication Date:
      Date Created: 20240201 Date Completed: 20240430 Latest Revision: 20240516
    • Publication Date:
      20250114
    • Accession Number:
      10.1093/jb/mvae006
    • Accession Number:
      38299708