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Cholesterol: A friend to viruses.

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  • Author(s): Wang Y;Wang Y; Gao L; Gao L
  • Source:
    International reviews of immunology [Int Rev Immunol] 2024; Vol. 43 (4), pp. 248-262. Date of Electronic Publication: 2024 Feb 19.
  • Publication Type:
    Journal Article; Review; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 8712260 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1563-5244 (Electronic) Linking ISSN: 08830185 NLM ISO Abbreviation: Int Rev Immunol Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: Chur ; New York : G+B/Harwood, 1986-
    • Subject Terms:
      Cholesterol*/metabolism ; Virus Diseases*/immunology ; Virus Diseases*/metabolism; Humans ; Animals ; Virus Internalization ; Virus Replication ; Host-Pathogen Interactions/immunology ; Immune Evasion ; Homeostasis ; Viruses/immunology ; Viruses/metabolism ; Signal Transduction
    • Abstract:
      Cholesterol is a key life-sustaining molecule which regulates membrane fluidity and serves as a signaling mediator. Cholesterol homeostasis is closely related to various pathological conditions including tumor, obesity, atherosclerosis, Alzheimer's disease and viral infection. Viral infection disrupts host cholesterol homeostasis, facilitating their own survival. Meanwhile, the host cells strive to reduce cholesterol accessibility to limit viral infection. This review focuses on the regulation of cholesterol metabolism and the role of cholesterol in viral infection, specifically providing an overview of cholesterol as a friend to promote viral entry, replication, assembly, release and immune evasion, which might inspire valuable thinking for pathogenesis and intervention of viral infection.
    • Contributed Indexing:
      Keywords: Antiviral therapy; cholesterol metabolism; host defense; viral infection
      Local Abstract: [plain-language-summary] Cholesterol is a metabolically important molecule. The disruption of cholesterol homeostasis is closely related to various diseases including tumor, atherosclerosis and Alzheimer’s disease. Moreover, viral infection is a highly cholesterol-dependent process. Important stages in the life cycle of viruses require the involvement of cholesterol. Viral infection breaks the cholesterol homeostasis in host cells, which is conducive to their own survival. This review aims to characterize the regulation of cholesterol metabolism and the role of cholesterol in viral infection, which would shed new light on the design of antiviral drugs.
    • Accession Number:
      97C5T2UQ7J (Cholesterol)
    • Publication Date:
      Date Created: 20240219 Date Completed: 20240612 Latest Revision: 20250521
    • Publication Date:
      20250522
    • Accession Number:
      10.1080/08830185.2024.2314577
    • Accession Number:
      38372266