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Educational inequalities in major depressive disorder prevalence, timing and duration among adults over the life course: a microsimulation analysis based on the Lifelines Cohort Study.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 9204966 Publication Model: Print Cited Medium: Internet ISSN: 1464-360X (Electronic) Linking ISSN: 11011262 NLM ISO Abbreviation: Eur J Public Health Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Oxford University Press
      Original Publication: Stockholm, Sweden : Almqvist & Wiksell International, c1991-
    • Subject Terms:
      Depressive Disorder, Major*/epidemiology ; Educational Status*; Humans ; Adult ; Female ; Middle Aged ; Prevalence ; Male ; Adolescent ; Netherlands/epidemiology ; Aged ; Young Adult ; Prospective Studies ; Cohort Studies ; Socioeconomic Factors ; Health Status Disparities ; Time Factors ; Computer Simulation
    • Abstract:
      Background: Educational inequalities in major depressive disorder (MDD) pose a major challenge. Tackling this issue requires evidence on the long-term impact of intervening on modifiable factors, for example lifestyle and psychosocial factors. For this reason, we aimed to simulate the development of educational inequalities in MDD across the life course, and to estimate the potential impact of intervening on modifiable factors.
      Methods: We used data from the prospective Dutch Lifelines Cohort Study to estimate the required input for a continuous-time microsimulation. The microsimulation allowed us to project the development of educational inequalities in MDD between ages 18 and 65, and to assess the potential benefit of intervening on quality of social contacts, health literacy and smoking.
      Results: On average, an additional 19.1% of individuals with low education will ever experience MDD between ages 18 and 65 compared with those with high education. Additionally, individuals with low education generally will develop MDD 0.9 years earlier and spend 1.2 years more with MDD, than individuals with high education. Improving the quality of social contacts in individuals with low education produced the largest effect; it would reduce the inequalities in the prevalence, onset and duration of MDD by an average of 18.4%, 18.3% and 28.6%, respectively.
      Conclusions: Intervening on modifiable factors, particularly quality of social contacts, in individuals with low education could help reduce the estimated educational inequalities in MDD over the life course.
      (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Public Health Association.)
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    • Grant Information:
      ZonMw The Netherlands Organization for Health Research and Development; 531003011 The Netherlands Organization for Health Research and Development
    • Publication Date:
      Date Created: 20240413 Date Completed: 20240801 Latest Revision: 20240803
    • Publication Date:
      20250114
    • Accession Number:
      PMC11293816
    • Accession Number:
      10.1093/eurpub/ckae066
    • Accession Number:
      38614471