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Ultrasound-Assisted Extraction of Phenolic Compounds from Celtuce ( Lactuca sativa var. augustana ) Leaves Using Natural Deep Eutectic Solvents (NADES): Process Optimization and Extraction Mechanism Research.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, c1995-
    • Subject Terms:
      Phenols*/chemistry ; Phenols*/isolation & purification ; Plant Leaves*/chemistry ; Lactuca*/chemistry ; Deep Eutectic Solvents*/chemistry; Plant Extracts/chemistry ; Ultrasonic Waves ; Spectroscopy, Fourier Transform Infrared ; Molecular Dynamics Simulation ; Solvents/chemistry
    • Abstract:
      Natural deep eutectic solvents (NADESs), as emerging green solvents, can efficiently extract natural products from natural resources. However, studies on the extraction of phenolic compounds from celtuce ( Lactuca sativa var. augustana ) leaves (CLs) by NADESs are still lacking. This study screened the NADES L-proline-lactic acid (Pr-LA), combined it with ultrasound-assisted extraction (UAE) to extract phenolic compounds from CLs, and conducted a comparative study on the extraction effect with traditional extraction solvents. Both SEM and FT-IR confirmed that Pr-LA can enhance the degree of fragmentation of cell structures and improve the extraction rate of phenolic compounds. Molecular dynamics simulation results show that Pr-LA can improve the solubility of phenolic compounds and has stronger hydrogen bonds and van der Waals interactions with phenolic compounds. Single-factor and Box-Behnken experiments optimized the process parameters for the extraction of phenolic compounds from CLs. The second-order kinetic model describes the extraction process of phenolic compounds from CLs under optimal process parameters and provides theoretical guidance for actual industrial production. This study not only provides an efficient and green method for extracting phenolic compounds from CLs but also clarifies the mechanism of improved extraction efficiency, which provides a basis for research on the NADES extraction mechanism.
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    • Grant Information:
      No. 12372313 and NO.31700816 National Natural Science Foundation of China; no number Collaborative Innovation Center of Fragrance Flavour and Cosmetics
    • Contributed Indexing:
      Keywords: celtuce (Lactuca sativa var. augustana) leaves; molecular dynamics; natural deep eutectic solvent; phenolic compounds; ultrasonic-assisted extraction
    • Accession Number:
      0 (Phenols)
      0 (Deep Eutectic Solvents)
      0 (Plant Extracts)
      0 (Solvents)
    • Publication Date:
      Date Created: 20240525 Date Completed: 20240525 Latest Revision: 20240527
    • Publication Date:
      20250114
    • Accession Number:
      PMC11124495
    • Accession Number:
      10.3390/molecules29102385
    • Accession Number:
      38792246