Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Systemic Inflammation Disrupts Circadian Rhythms and Diurnal Neuroimmune Dynamics.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, [2000-
    • Subject Terms:
      Circadian Rhythm* ; Inflammation* ; Lipopolysaccharides*; Animals ; Mice ; Male ; Microglia/metabolism ; Microglia/immunology ; Hypothalamus/metabolism ; Hypothalamus/immunology ; Hippocampus/metabolism ; Cytokines/metabolism ; Liver/metabolism ; Liver/pathology ; Liver/immunology ; Mice, Inbred C57BL ; Circadian Clocks/genetics ; Neuroimmunomodulation
    • Abstract:
      Circadian rhythms regulate physiological processes in approximately 24 h cycles, and their disruption is associated with various diseases. Inflammation may perturb circadian rhythms, though these interactions remain unclear. This study examined whether systemic inflammation induced by an intraperitoneal injection of lipopolysaccharide (LPS) could alter central and peripheral circadian rhythms and diurnal neuroimmune dynamics. Mice were randomly assigned to two groups: the saline control group and the LPS group. The diurnal expression of circadian clock genes and inflammatory cytokines were measured in the hypothalamus, hippocampus, and liver. Diurnal dynamic behaviors of microglia were also assessed. Our results revealed that the LPS perturbed circadian gene oscillations in the hypothalamus, hippocampus, and liver. Furthermore, systemic inflammation induced by the LPS could trigger neuroinflammation and perturb the diurnal dynamic behavior of microglia in the hippocampus. These findings shed light on the intricate link between inflammation and circadian disruption, underscoring their significance in relation to neurodegenerative diseases.
    • References:
      Science. 2000 Apr 28;288(5466):682-5. (PMID: 10784453)
      Int J Mol Sci. 2023 Feb 08;24(4):. (PMID: 36834801)
      J Vis Exp. 2018 Jun 5;(136):. (PMID: 29939190)
      J Neurosci Res. 2023 Apr;101(4):524-540. (PMID: 36583371)
      Int J Mol Sci. 2022 Nov 08;23(22):. (PMID: 36430199)
      J Clin Invest. 2021 Oct 1;131(19):. (PMID: 34596053)
      Immunology. 2020 Dec;161(4):261-267. (PMID: 31820826)
      Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):582-7. (PMID: 22184247)
      Occup Environ Med. 2010 Jan;67(1):54-7. (PMID: 19737731)
      Nat Commun. 2014 Sep 11;5:4753. (PMID: 25208554)
      Sci Rep. 2016 Jul 21;6:30006. (PMID: 27445174)
      J Neuroinflammation. 2018 May 17;15(1):147. (PMID: 29776428)
      Handb Exp Pharmacol. 2013;(217):3-27. (PMID: 23604473)
      Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5339-46. (PMID: 14963227)
      Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21407-12. (PMID: 19955445)
      Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5102-5107. (PMID: 30792350)
      J Immunol. 2010 Nov 15;185(10):5796-805. (PMID: 20944004)
      Front Neuroendocrinol. 2019 Jul;54:100764. (PMID: 31102663)
      Curr Sleep Med Rep. 2017 Jun;3(2):76-84. (PMID: 28845384)
      J Immunol. 2016 Mar 15;196(6):2466-75. (PMID: 26873990)
      J Neuroinflammation. 2023 Mar 13;20(1):71. (PMID: 36915108)
      J Neurochem. 2002 Dec;83(5):1215-25. (PMID: 12437593)
      J Neuroimmunol. 2008 Jan;193(1-2):24-7. (PMID: 17936367)
      Brain Behav Immun. 2015 Jul;47:14-23. (PMID: 25542734)
      Food Res Int. 2020 Nov;137:109437. (PMID: 33233118)
      Ageing Res Rev. 2022 Jun;78:101620. (PMID: 35405323)
      Exp Neurol. 2017 Aug;294:58-67. (PMID: 28461004)
      FASEB J. 2017 Nov;31(11):4707-4719. (PMID: 28710114)
      Nat Rev Neurol. 2014 Dec;10(12):683-93. (PMID: 25385339)
      Obes Rev. 2022 Oct;23(10):e13489. (PMID: 35734805)
      J Immunol. 2014 Jan 1;192(1):407-17. (PMID: 24307731)
      Int J Mol Sci. 2020 Mar 10;21(5):. (PMID: 32164209)
      Int J Mol Sci. 2020 Dec 21;21(24):. (PMID: 33371208)
      Carbohydr Polym. 2021 Sep 01;267:118216. (PMID: 34119170)
    • Grant Information:
      A0046611 The Hong Kong Polytechnic University (UGC)
    • Contributed Indexing:
      Keywords: circadian disruption; clock gene expression; microglia; peripheral circadian clocks
    • Accession Number:
      0 (Lipopolysaccharides)
      0 (Cytokines)
    • Publication Date:
      Date Created: 20240713 Date Completed: 20240713 Latest Revision: 20240715
    • Publication Date:
      20250114
    • Accession Number:
      PMC11242289
    • Accession Number:
      10.3390/ijms25137458
    • Accession Number:
      39000563