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The role of gut microbiota in different murine models of systemic lupus erythematosus.

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  • Author(s): Lu R;Lu R; Luo XM; Luo XM
  • Source:
    Autoimmunity [Autoimmunity] 2024 Dec; Vol. 57 (1), pp. 2378876. Date of Electronic Publication: 2024 Jul 16.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 8900070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-842X (Electronic) Linking ISSN: 08916934 NLM ISO Abbreviation: Autoimmunity Subsets: MEDLINE
    • Publication Information:
      Publication: 2015- : Abingdon, Oxford : Taylor & Francis
      Original Publication: Chur ; New York : Harwood, c1988-
    • Subject Terms:
      Lupus Erythematosus, Systemic*/immunology ; Lupus Erythematosus, Systemic*/microbiology ; Gastrointestinal Microbiome*/immunology ; Dysbiosis*/immunology ; Dysbiosis*/microbiology ; Disease Models, Animal*; Animals ; Mice ; Humans
    • Abstract:
      Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by immune system dysfunction that can lead to serious health issues and mortality. Recent investigations highlight the role of gut microbiota alterations in modulating inflammation and disease severity in SLE. This review specifically summaries the variations in gut microbiota composition across various murine models of lupus. By focusing on these differences, we aim to elucidate the intricate relationship between gut microbiota dysbiosis and the development and progression of SLE in preclinical settings.
    • Contributed Indexing:
      Keywords: Lupus; SLE; gut microbiota; immune dysregulation; leaky gut; molecular mimicry; mouse models
    • Publication Date:
      Date Created: 20240717 Date Completed: 20240717 Latest Revision: 20250710
    • Publication Date:
      20260130
    • Accession Number:
      10.1080/08916934.2024.2378876
    • Accession Number:
      39014962