Formulation of Polymeric Micelles to Increase the Solubility and Photostability of Caffeic Acid.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, c1995-

Caffeic Acids*/chemistry ; Micelles* ; Solubility* ; Polymers*/chemistry; Antioxidants/chemistry ; Drug Stability ; Drug Liberation ; Drug Compounding ; Particle Size ; Drug Carriers/chemistry

Caffeic acid (CA), a hydrophobic polyphenol with various pharmacological activities, exhibits a low aqueous solubility and sensitivity to light. In order to improve its chemical properties and overcome the limits in its application, the compound was loaded in P123 micelles (MCs) prepared using two polymer concentrations (10 and 20% w / w , MC10 and MC20). The micelles were characterised in terms of the size distribution, zeta potential, drug encapsulation efficiency, rheology, and cumulative drug release. Micellar formulations exhibited sizes in the range of 11.70 and 17.70 nm and a good polydispersion, indicating the formation of relatively small-sized micelles, which is favourable for drug delivery applications. Additionally, the stability and antioxidant profiles of the free CA and the CA loaded in micelles were studied. The results obtained on the free CA showed the formation of photodegradation products endowed with higher DPPH scavenging activity with respect to the pure compound. Instead, it was found that the incorporation of CA into the micelles significantly increased its solubility and decreased the photodegradation rate. Overall, the results indicate the successful formation of P123 micelles loaded with CA, with promising characteristics such as a small size, good encapsulation efficiency, sustained release profile, and improved light stability. These findings suggest the potentiality of these micelles as a delivery system for CA, thus enhancing its bioavailability.

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Keywords: P123; antioxidant activity; caffeic acid; photodegradation studies; polymeric micelles; release studies; skin permeation

0 (Caffeic Acids)
0 (Micelles)
U2S3A33KVM (caffeic acid)
0 (Polymers)
0 (Antioxidants)
0 (Drug Carriers)

Date Created: 20240727 Date Completed: 20240728 Latest Revision: 20240729

20250114

PMC11279489

10.3390/molecules29143329

39064907