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The evidence from in vitro primary fibroblasts and a randomized, double-blind, placebo-controlled clinical trial of tuna collagen peptides intake on skin health.

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  • Additional Information
    • Source:
      Publisher: Blackwell Science Country of Publication: England NLM ID: 101130964 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-2165 (Electronic) Linking ISSN: 14732130 NLM ISO Abbreviation: J Cosmet Dermatol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford, UK : Blackwell Science, c2002-
    • Subject Terms:
      Tuna* ; Fibroblasts*/drug effects ; Collagen*; Humans ; Double-Blind Method ; Female ; Animals ; Adult ; Elastin/metabolism ; Skin/drug effects ; Middle Aged ; Cells, Cultured ; Skin Aging/drug effects ; Young Adult ; Elasticity/drug effects ; Cellular Senescence/drug effects
    • Abstract:
      Background: Collagen peptides from various sources demonstrate benefits in health and well-being both in vitro and in clinical trials. However, there is a scarce study of collagen peptides from Tuna on skin health.
      Aims: To investigate the impact of collagen peptides derived from Tuna (Katsuwonus pelamis and Thunnus albacares) on skin health, utilizing in vitro biological studies and a randomized controlled trial.
      Methods: In vitro biological studies on human dermal primary fibroblasts were evaluated in terms of collagen and elastin synthesis and senescent cell inhibition. A randomized, placebo-controlled, double-blind clinical trial was conducted on 72 women who were randomly assigned to receive either tuna collagen peptides (n = 36) or a placebo (n = 36) orally for 8 weeks and 2 weeks post-ingestion by measuring skin hydration, transepidermal water loss (TEWL), skin elasticity, and skin density.
      Results: In vitro biological effects demonstrated dose-dependent positive results in increasing collagen and elastin synthesis and reducing senescent cells. The effects on collagen and senescent cells plateaued at high concentrations. A clinical trial showed that the test group experienced a significant increase in skin hydration, elasticity, and density, along with a decrease in TEWL compared to the baseline. The test and placebo groups showed statistically significant differences at 8 weeks for all parameters except for the TEWL at the face. All positive effects were substantially retained even after 2 weeks of discontinuation.
      Conclusions: These findings demonstrate the significant potential of tuna collagen peptides to promote human skin health, warranting further investigation as a potential nutraceutical.
      (© 2024 The Author(s). Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.)
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    • Grant Information:
      C10F650107 Office of National Higher Education Science Research and Innovation Policy Council through the Program Management Unit for Competitiveness and Thai Union Group PCL
    • Contributed Indexing:
      Keywords: collagen peptides; density; elasticity; hydration; transepidermal water loss
    • Accession Number:
      9007-34-5 (Collagen)
      9007-58-3 (Elastin)
    • Publication Date:
      Date Created: 20240730 Date Completed: 20241209 Latest Revision: 20241227
    • Publication Date:
      20250114
    • Accession Number:
      PMC11626298
    • Accession Number:
      10.1111/jocd.16500
    • Accession Number:
      39075819