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COVID-19 in Brazilian Pediatric Patients: A Retrospective Cross-Sectional Study with a Predictive Model for Hospitalization.

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  • Additional Information
    • Source:
      Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101580444 Publication Model: Electronic Cited Medium: Print ISSN: 2075-1729 (Print) Linking ISSN: 20751729 NLM ISO Abbreviation: Life (Basel) Subsets: PubMed not MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI AG, 2011-
    • Abstract:
      Background: This study was conducted to ascertain the most frequent symptoms of COVID-19 infection at first consultation in a pediatric cohort and to devise a predictive model for hospitalization.
      Methods: This is a retrospective cross-sectional study of 1028 Brazilian patients aged <18 years with SARS-CoV-2 infection in a single reference hospital in the first year of the pandemic. Clinical, demographic, laboratory, and disease spectrum data were analyzed via multivariate logistic regression modeling to develop a predictive model of factors linked to hospitalization.
      Results: The majority of our cohort were schoolchildren and adolescents, with a homogeneous distribution concerning sex. At first consultation, most patients presented with fever (64.1%) and respiratory symptoms (63.3%). We had 204 admitted patients, including 11 with Pediatric Multisystem Inflammatory Syndrome. Increased D-dimer levels were associated with comorbidities (p = 0.018). A high viral load was observed in patients within the first two days of symptoms (p < 0.0001). Our predictive model included respiratory distress, number and type of specific comorbidities, tachycardia, seizures, and vomiting as factors for hospitalization.
      Conclusions: Most patients presented with mild conditions with outpatient treatment. However, understanding predictors for hospitalization can contribute to medical decisions at the first patient visit.
    • References:
      JAMA. 2020 Apr 7;323(13):1239-1242. (PMID: 32091533)
      Clin Chem Lab Med. 2020 Jun 25;58(7):1135-1138. (PMID: 32172227)
      Lancet Child Adolesc Health. 2021 Aug;5(8):559-568. (PMID: 34119027)
      Acta Paediatr. 2020 Jun;109(6):1088-1095. (PMID: 32202343)
      Rev Paul Pediatr. 2022 Apr 04;40:e2021367. (PMID: 35442272)
      BMC Pediatr. 2021 Sep 13;21(1):403. (PMID: 34517879)
      Science. 2020 May 1;368(6490):489-493. (PMID: 32179701)
      JAMA Netw Open. 2021 Jun 1;4(6):e2115850. (PMID: 34081135)
      JAMA. 2020 Apr 14;323(14):1335. (PMID: 32181795)
      Pediatr Pulmonol. 2020 Aug;55(8):1892-1899. (PMID: 32492251)
      Rev Paul Pediatr. 2020 Nov 27;39:e2020305. (PMID: 33263697)
      J Pediatr. 2020 Nov;226:45-54.e1. (PMID: 32768466)
      Pediatr Int. 2022 Jan;64(1):e14890. (PMID: 34145691)
      Rev Med Virol. 2021 Jul;31(4):e2199. (PMID: 34260778)
      J Infect Dis. 2021 Dec 1;224(11):1821-1829. (PMID: 34647601)
      Am J Otolaryngol. 2020 Sep - Oct;41(5):102573. (PMID: 32531620)
      N Engl J Med. 2020 Jul 23;383(4):347-358. (PMID: 32598830)
      Braz J Med Biol Res. 2022 Jun 13;55:e12038. (PMID: 35703681)
      Pediatr Infect Dis J. 2020 Jul;39(7):e91-e94. (PMID: 32384397)
    • Contributed Indexing:
      Keywords: SARS-CoV-2; hospitalization; pediatrics
    • Publication Date:
      Date Created: 20240928 Latest Revision: 20240930
    • Publication Date:
      20260130
    • Accession Number:
      PMC11433062
    • Accession Number:
      10.3390/life14091083
    • Accession Number:
      39337867