Causal relationship between rheumatoid arthritis and carpal tunnel syndrome: a bidirectional two-sample Mendelian randomization study.

Publisher: BioMed Central Country of Publication: England NLM ID: 101265112 Publication Model: Electronic Cited Medium: Internet ISSN: 1749-799X (Electronic) Linking ISSN: 1749799X NLM ISO Abbreviation: J Orthop Surg Res Subsets: MEDLINE

Original Publication: London : BioMed Central, 2006-

Carpal Tunnel Syndrome*/genetics ; Carpal Tunnel Syndrome*/etiology ; Carpal Tunnel Syndrome*/epidemiology ; Arthritis, Rheumatoid*/genetics ; Arthritis, Rheumatoid*/complications ; Mendelian Randomization Analysis* ; Polymorphism, Single Nucleotide* ; Genome-Wide Association Study*; Humans ; Causality

Background: Although there is considerable evidence of a robust correlation between rheumatoid arthritis (RA) and carpal tunnel syndrome (CTS) in previous research, the causal link between the two remains a topic of controversy.
Methods: We conducted a two-sample Mendelian randomization (MR) study to explore the causal impact of RA on CTS. We obtained aggregate data from genome-wide association studies (GWAS) of CTS (ebi database and GEO database) and RA (FinnGen database). This study employed five MR analysis methods, with a focus on the inverse variance-weighted (IVW) method. Sensitivity analyses were conducted to ensure the robustness of the results of this study. Additionally, we performed reverse MR analysis.
Results: We selected 84 and 78 single nucleotide polymorphisms (SNPs) significantly associated with RA from two databases as instrumental variables (IVs), respectively. Our results showed that RA patients have a higher risk of getting CTS regardless of whether the ebi database (IVW, OR = 1.045, 95% CI: 1.016-1.075, P = 0.002) or the GEO database (IVW, OR = 1.001, 95% CI: 1.001-1.002, P = 0.001) is selected for CTS data. However, the MR analysis showed no causal link between CTS and the increased risk of RA (ebi: IVW, OR = 1.084, 95% CI: 0.918-1.279, P = 0.341; GEO: IVW, OR = 1.968, 95% CI: 0.011-360.791, P = 0.799).
Conclusion: The analysis revealed that RA can increase the risk of CTS, but did not support the causal relationship that CTS can increase the risk of RA.
(© 2024. The Author(s).)

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ZR2023MH225 the Natural Science Foundation of Shandong Provinc

Keywords: Carpal tunnel syndrome; Causal relationship; GWAS; Mendelian randomization; Rheumatoid arthritis

Date Created: 20240929 Date Completed: 20240929 Latest Revision: 20241003

20250114

PMC11441067

10.1186/s13018-024-05059-2

39343950