Per and poly-fluoroalkyl substances and respiratory health in an Inuit community.

Publisher: BioMed Central Country of Publication: England NLM ID: 101147645 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-069X (Electronic) Linking ISSN: 1476069X NLM ISO Abbreviation: Environ Health Subsets: MEDLINE

Original Publication: London : BioMed Central, [2002-

Inuit* ; Fluorocarbons*/blood ; Environmental Pollutants*/blood; Humans ; Adult ; Middle Aged ; Male ; Female ; Aged ; Young Adult ; Adolescent ; Aged, 80 and over ; Asthma/epidemiology ; Asthma/chemically induced ; Environmental Exposure/adverse effects ; Nunavut/epidemiology

Background: Concentrations of plasma per and poly-fluoroalkyl substances (PFAS) are elevated in the Inuit population of Nunavik and may be causing adverse health effects. Respiratory health outcomes have been associated with PFAS, but have not been explored in Inuit communities. The aim of the study was to examine the association between PFAS and respiratory health outcomes, and the moderating role of nutritional biomarkers.
Methods: We included up to 1298 participants of the Qanuilirpitaa? 2017 survey aged 16-80 years. Generalized regression models were used to estimate the associations between six individual PFAS congeners and four self-reported symptoms, four spirometry measures, and physician-diagnosed asthma. Outcomes associated with PFAS from single chemical models were further explored using Bayesian Kernel Machine Regression (BKMR). The modifying effect of n-3 PUFA in red blood cell quartiles and vitamin D deficiency were examined on the associations between PFAS and respiratory outcomes.
Results: PFNA and PFOS were associated with asthma (odds ratio (OR) 1.61, 95% confidence interval (CI) 1.12, 2.32; OR 1.45 95% CI 1.04, 2.03). PFOA, PFNA, PFDA and PFHxS were associated with a decrease in the ratio between the forced expiratory volume in the first second and forced vital capacity (FEV1/FVC). No associations were observed with self-reported respiratory symptoms. No associations were observed between a PFAS mixture and asthma. Some associations were modified by nutritional factors, namely, stronger associations between PFOA and PFHxS and asthma with lower n-3 PUFA levels and stronger associations between PFDA, PFUnDA and PFOS and FEV1/FVC with vitamin D deficiency.
Conclusion: These findings add to the growing literature on the impacts of PFAS on respiratory health, and the importance of their global regulation. Associations were modified by nutritional factors pointing to the nutritional value of traditional Inuit foods.
(© 2024. The Author(s).)

Environ Sci Technol. 2018 Mar 20;52(6):3738-3747. (PMID: 29516726)
Environ Sci Pollut Res Int. 2023 Apr;30(18):53948-53961. (PMID: 36869952)
Prostaglandins Leukot Essent Fatty Acids. 2010 Sep;83(3):143-50. (PMID: 20634051)
Nutrients. 2023 Aug 22;15(17):. (PMID: 37686715)
Nat Commun. 2021 May 18;12(1):2915. (PMID: 34006824)
Eur Respir J. 2011 Dec;38(6):1287-93. (PMID: 21565920)
Int J Hyg Environ Health. 2020 Aug;229:113565. (PMID: 32485600)
Heliyon. 2021 Oct 12;7(10):e08160. (PMID: 34712855)
Br J Nutr. 2011 Aug;106(3):441-50. (PMID: 21443816)
Cureus. 2021 Aug 18;13(8):e17279. (PMID: 34462708)
Environ Res. 2021 Jan;192:110178. (PMID: 32991923)
Stat Med. 2011 Feb 20;30(4):377-99. (PMID: 21225900)
Am J Clin Nutr. 2010 Aug;92(2):408-15. (PMID: 20554789)
Eur J Pharmacol. 2016 Aug 15;785:174-186. (PMID: 27041644)
PLoS One. 2013 Nov 12;8(11):e80048. (PMID: 24265794)
Biostatistics. 2015 Jul;16(3):493-508. (PMID: 25532525)
Environ Pollut. 2019 Sep;252(Pt B):1335-1343. (PMID: 31252131)
Sci Total Environ. 2015 Mar 15;509-510:248-59. (PMID: 25135671)
Sci Total Environ. 2023 Jun 20;878:162759. (PMID: 36907407)
Sci Total Environ. 2023 Jan 20;857(Pt 3):159557. (PMID: 36272489)
Environ Res. 2019 Feb;169:114-121. (PMID: 30447498)
Environ Sci Pollut Res Int. 2019 Oct;26(29):29639-29648. (PMID: 31399834)
J Expo Sci Environ Epidemiol. 2019 Mar;29(2):148-156. (PMID: 30482935)
Int J Environ Res Public Health. 2016 May 23;13(5):. (PMID: 27223295)
Eur Respir J. 2017 Apr 26;49(4):. (PMID: 28446555)
Eur Respir J. 2015 May;45(5):1479-81. (PMID: 25657027)
Respir Res. 2022 Sep 19;23(1):252. (PMID: 36117182)
Chest. 1988 Mar;93(3):580-6. (PMID: 3342669)
J Allergy Clin Immunol Glob. 2023 May;2(2):. (PMID: 37274185)
Int J Mol Sci. 2023 May 10;24(10):. (PMID: 37239886)
Eur Respir J. 2005 Nov;26(5):948-68. (PMID: 16264058)
Environ Toxicol Chem. 2021 Mar;40(3):606-630. (PMID: 33017053)
Environ Toxicol Chem. 2021 Mar;40(3):631-657. (PMID: 33201517)
Environ Health Perspect. 2013 Apr;121(4):507-13. (PMID: 23309686)
Thorax. 2004 Feb;59(2):105-10. (PMID: 14760147)
Respir Med. 2019 Jul - Aug;154:56-62. (PMID: 31212122)
Environ Res. 2019 May;172:266-272. (PMID: 30822559)
Environ Res. 2017 May;155:15-21. (PMID: 28171771)
Environ Sci Pollut Res Int. 2023 May;30(24):65646-65658. (PMID: 37085680)
Allergy. 2015 Jun;70(6):653-60. (PMID: 25753462)
Chest. 2009 Jun;135(6):1440-1447. (PMID: 19188556)
Environ Health. 2019 Nov 15;18(1):97. (PMID: 31730470)
Environ Res. 2020 Dec;191:110145. (PMID: 32877702)
J Immunotoxicol. 2023 Dec;20(1):2176953. (PMID: 36788734)
Environ Health Perspect. 2014 Oct;122(10):1129-33. (PMID: 24905661)
Environ Int. 2019 Mar;124:462-472. (PMID: 30684804)
Am J Respir Crit Care Med. 2010 Sep 1;182(5):693-718. (PMID: 20802169)
Sci Total Environ. 2016 Jul 15;559:166-173. (PMID: 27060656)
Environ Geochem Health. 2023 Aug;45(8):5981-5990. (PMID: 37195568)
Respir Med. 2010 Dec;104(12):1793-8. (PMID: 20637584)
Cochrane Database Syst Rev. 2023 Feb 6;2:CD011511. (PMID: 36744416)
J Glob Health. 2022 Dec 16;12:04100. (PMID: 36520525)
Respir Res. 2023 Mar 16;24(1):82. (PMID: 36927379)
J Allergy Clin Immunol. 2014 May;133(5):1255-64. (PMID: 24613565)
Crit Rev Toxicol. 2016;46(4):279-331. (PMID: 26761418)
Toxicol In Vitro. 2020 Feb;62:104656. (PMID: 31536757)
Environ Int. 2020 Jan;134:105259. (PMID: 31733527)
Environ Sci Pollut Res Int. 2013 Nov;20(11):7930-9. (PMID: 23686789)
Transl Pediatr. 2021 Feb;10(2):323-332. (PMID: 33708518)
Lung India. 2023 Sep-Oct;40(5):449-456. (PMID: 37787360)
Can J Public Health. 2024 Jan;115(Suppl 1):136-151. (PMID: 36624337)
Environ Res. 2018 Jan;160:518-523. (PMID: 29106950)
Environ Sci Pollut Res Int. 2023 Apr;30(18):52535-52548. (PMID: 36840869)
Respir Res. 2019 Oct 8;20(1):161. (PMID: 31590675)
Am J Respir Crit Care Med. 1999 Jan;159(1):179-87. (PMID: 9872837)
Sci Total Environ. 2021 Apr 20;766:142365. (PMID: 33601665)
Eur Respir J. 2012 Jun;39(6):1343-53. (PMID: 22183479)
Lancet Planet Health. 2019 Feb;3(2):e81-e92. (PMID: 30737192)
Environ Int. 2013 Sep;59:354-62. (PMID: 23892228)
Environ Sci Pollut Res Int. 2023 Jun;30(29):73485-73496. (PMID: 37191746)
Front Pediatr. 2019 Jun 25;7:256. (PMID: 31294006)
Can J Public Health. 2024 Jan;115(Suppl 1):7-19. (PMID: 38231467)
Int J Environ Res Public Health. 2018 Dec 25;16(1):. (PMID: 30585204)
Am J Clin Nutr. 2022 Mar 4;115(3):886-896. (PMID: 34964829)
Arch Toxicol. 2011 Oct;85(10):1235-44. (PMID: 21327619)
J Expo Sci Environ Epidemiol. 2019 Mar;29(2):131-147. (PMID: 30470793)
Int J Circumpolar Health. 2005 Apr;64(2):163-9. (PMID: 15945286)
BMC Public Health. 2012 Mar 19;12:204. (PMID: 22429515)
Environ Res. 2017 Nov;159:158-163. (PMID: 28802206)
Public Health Nutr. 2018 Aug;21(11):1988-1994. (PMID: 29433587)
Public Health Nutr. 2024 Feb 22;27(1):e81. (PMID: 38384120)
Environ Health Perspect. 2017 Jun 26;125(6):067015. (PMID: 28669934)
Chemosphere. 2023 Jan;310:136797. (PMID: 36244416)

H-13 Northern Contaminants Program; H-13 Northern Contaminants Program; H-13 Northern Contaminants Program; H-13 Northern Contaminants Program

0 (Fluorocarbons)
0 (Environmental Pollutants)

Date Created: 20241011 Date Completed: 20241012 Latest Revision: 20241023

20250114

PMC11470554

10.1186/s12940-024-01126-7

39394583