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Human Amniotic Membrane: A Seal for Complex Retinal Detachments.

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  • Additional Information
    • Source:
      Publisher: Galenos Yayınevi Country of Publication: Turkey NLM ID: 101686048 Publication Model: Print Cited Medium: Internet ISSN: 2149-8709 (Electronic) Linking ISSN: 21498709 NLM ISO Abbreviation: Turk J Ophthalmol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Fındıkzade-İstanbul, Türkiye : Galenos Yayınevi, [2015]-
    • Subject Terms:
      Amnion*/transplantation ; Visual Acuity* ; Retinal Detachment*/surgery ; Retinal Detachment*/diagnosis ; Tomography, Optical Coherence*/methods; Humans ; Retrospective Studies ; Female ; Male ; Child ; Adult ; Child, Preschool ; Adolescent ; Middle Aged ; Follow-Up Studies ; Young Adult ; Infant ; Aged ; Infant, Newborn ; Vitrectomy/methods ; Treatment Outcome
    • Abstract:
      Objectives: To evaluate the efficacy of human amniotic membrane (hAM) transplantation for complex retinal detachments (RD).
      Materials and Methods: A retrospective analysis of consecutive patients who underwent vitreoretinal surgery with hAM transplantation for complex RD was conducted. The indications included high myopic macular hole (MH)-associated RD (n=5), traumatic large macular tears (n=4), combined RD with MH due to cicatricial retinopathy of prematurity (n=2) and severe retinitis (n=1), and morning glory syndrome (n=1). Surgical procedures, anatomical and functional results, and complications were noted.
      Results: Thirteen eyes of 13 patients with a median age of 7 years (range, 0-65 years) were included. The follow-up was 15 months (range, 6-30 months). All eyes achieved MH sealing. Sealing occurred after a single surgery in 75% of eyes, while 25% required a second surgery due to hAM contraction/dislocation. The retina was attached and silicone oil could be removed in 92% of eyes during follow-up. The mean logarithm of the minimum angle of resolution visual acuity increased from 2.08±0.49 to 1.78±0.70 (p=0.07). Optical coherence tomography showed good integration of the hAM grafts with the retina, albeit without discernible retinal layer differentiation in any case.
      Conclusion: Amniotic membrane grafting appears to be promising for anatomical sealing of MHs and posterior retinal tears in complex RDs such as those associated with degenerative myopia, severe trauma, tractional membranes, and retinal shortening, where conventional surgical techniques are likely to fail. Further research is needed to clarify the regenerative potential and functional capacity of hAM grafts in severe retinal pathologies.
      (©Copyright 2024 by the Turkish Ophthalmological Association / Turkish Journal of Ophthalmology published by Galenos Publishing House.)
    • Abstract:
      Conflict of Interest: No conflict of interest was declared by the authors.
    • References:
      Sci Rep. 2020 Oct 26;10(1):18264. (PMID: 33106542)
      Indian J Ophthalmol. 2002 Sep;50(3):227-31. (PMID: 12355703)
      Retina. 2020 Nov;40(11):2134-2139. (PMID: 31876885)
      Retin Cases Brief Rep. 2024 Jan 1;18(1):18-23. (PMID: 35944558)
      Ophthalmology. 2019 Oct;126(10):1399-1408. (PMID: 30711606)
      Mol Vis. 2005 Jan 06;11:1-10. (PMID: 15660020)
      J Ophthalmol. 2020 Jul 07;2020:9157518. (PMID: 32724671)
      Clin Ophthalmol. 2020 Aug 24;14:2411-2416. (PMID: 32904754)
      Ophthalmic Surg Lasers Imaging Retina. 2020 Feb 1;51(2):101-108. (PMID: 32084283)
      Med Hypotheses. 2015 Aug;85(2):197-202. (PMID: 25997985)
      Burns. 2020 Sep;46(6):1254-1271. (PMID: 31445711)
      Am J Ophthalmol. 2014 Apr;157(4):861-869.e1. (PMID: 24418265)
      Retina. 2016 Jan;36(1):163-70. (PMID: 26200509)
      Retina. 2018 Nov;38(11):2177-2183. (PMID: 29045320)
      Acta Ophthalmol. 2019 Dec;97(8):821-823. (PMID: 30953398)
      Ophthalmic Res. 2019;61(2):88-93. (PMID: 29788031)
      Retina. 2019 Oct;39 Suppl 1:S95-S103. (PMID: 30312261)
      J Curr Ophthalmol. 2020 Dec 12;32(4):361-367. (PMID: 33553838)
      Eur J Ophthalmol. 2020 Mar;30(2):392-395. (PMID: 31766876)
      Case Rep Ophthalmol. 2020 Aug 6;11(2):442-447. (PMID: 32999674)
      Retina. 2020 Oct;40(10):1946-1954. (PMID: 31868775)
      Acta Ophthalmol. 2020 Mar;98(2):e252-e256. (PMID: 31318489)
      Acta Ophthalmol Scand. 2003 Jun;81(3):271-7. (PMID: 12780407)
      J Clin Med. 2023 Feb 01;12(3):. (PMID: 36769785)
      Acta Ophthalmol. 2022 Mar;100(2):e598-e608. (PMID: 33998147)
      Ophthalmol Retina. 2020 Oct;4(10):996-1007. (PMID: 32344157)
      Ocul Surf. 2004 Jul;2(3):177-87. (PMID: 17216089)
    • Contributed Indexing:
      Keywords: Human amniotic membrane; high myopia; macular hole; retinal detachment
    • Publication Date:
      Date Created: 20241028 Date Completed: 20241028 Latest Revision: 20250808
    • Publication Date:
      20250809
    • Accession Number:
      PMC11589237
    • Accession Number:
      10.4274/tjo.galenos.2024.56424
    • Accession Number:
      39463152