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Association of variabilities in body mass index and metabolic parameters with post-kidney transplantation renal outcomes.

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • Subject Terms:
      Kidney Transplantation*/adverse effects ; Body Mass Index* ; Metabolic Syndrome*; Humans ; Male ; Female ; Middle Aged ; Adult ; Risk Factors ; Glomerular Filtration Rate ; Blood Glucose/metabolism ; Graft Survival ; Treatment Outcome ; Kidney/physiopathology ; Kidney/metabolism ; Blood Pressure ; Republic of Korea/epidemiology
    • Abstract:
      Metabolic syndrome is a significant risk factor for poor graft outcomes in kidney transplant (KT) patients. However, the effects of variability in metabolic parameters on graft outcomes in KT patients have not been completely elucidated. A total of 852 KT patients were included from the Korean Organ Transplantation Registry. The study exposure was variability in body mass index (BMI) or other metabolic parameters measured at 6 months, 1 year, and 2 years after KT. Patients were classified into tertiles according to the degree of variability. The primary outcome was a composite of adverse kidney outcomes, such as death-censored graft loss or ≥ 30% decline in estimated glomerular filtration rate. The adverse kidney outcomes occurred in 73 (8.6%) participants. The high-BMI variability group had a higher risk for adverse kidney outcomes compared to the low-variability group. High variabilities in triglyceride, fasting blood glucose, and systolic blood pressure were also associated with adverse kidney outcomes. Furthermore, high variability in metabolic syndrome-related composite indices, such as the triglyceride and glucose index and metabolic variability scores, showed a higher risk for adverse kidney outcomes. In conclusion, high variability in metabolic parameters could be associated with an increased risk of adverse kidney outcome in KT patients.
      (© 2024. The Author(s).)
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    • Accession Number:
      0 (Blood Glucose)
    • Publication Date:
      Date Created: 20241106 Date Completed: 20241107 Latest Revision: 20241109
    • Publication Date:
      20250114
    • Accession Number:
      PMC11541543
    • Accession Number:
      10.1038/s41598-024-78079-x
    • Accession Number:
      39505975