Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Profiling CARD14 gene expression in Indian Psoriasis patients.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • Subject Terms:
      Psoriasis*/genetics ; Psoriasis*/metabolism ; Psoriasis*/pathology ; CARD Signaling Adaptor Proteins*/genetics ; CARD Signaling Adaptor Proteins*/metabolism ; Guanylate Cyclase*/genetics ; Guanylate Cyclase*/metabolism ; Membrane Proteins*/genetics ; Membrane Proteins*/metabolism; Humans ; Male ; Female ; India ; Adult ; Middle Aged ; Gene Expression Profiling ; Skin/metabolism ; Skin/pathology ; Young Adult ; Keratinocytes/metabolism
    • Abstract:
      Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
      Several Genome Wide linkage Studies on psoriasis performed to gain insight of genetic architecture of the disease. Caspase Recruitment Domain-containing family 14 (CARD14) also known as CARMA2 or BIMP2; cytogenic location: 17q25.3, is a scaffold protein that primarily controls the skin epidermis's nuclear factor kB (NF-kB) signaling pathway activity in skin epidermis, a master gene for inflammation, has been shown to be linked with rare, heritable form of psoriasis. CARD14 is predominantly expressed in keratinocytes and epithelial cells, but also in unidentified dermal cells. For better understanding of molecular processes involved in CARD14 underlying Indian psoriatic patients, we analyzed gene expression of 42 moderates to severe cases of plaque psoriasis and same number of controls using qPCR and its validation through Immunohistochemistry (IHC). This study identifies that the expression of CARD14 in dermal endothelial cells among patients with psoriasis and explores the potential functional consequences associated with an overactive CARD14 gene. Furthermore, the expression data from the western population was consistent with the results of the qPCR validation of the candidate gene. There is a significant correlation between Indian psoriasis vulgaris patients and CARD14 up-regulation, as evidenced by a roughly two-fold shift in lesional tissue expression. This provides insights into the pathways and genes linked to the pathogenesis of psoriasis.
      (© 2024. The Author(s).)
    • References:
      Biomedicines. 2021 Nov 23;9(12):. (PMID: 34944562)
      Gene. 2019 Jan 30;683:61-71. (PMID: 30287254)
      N Engl J Med. 2009 Jul 30;361(5):496-509. (PMID: 19641206)
      Nature. 2012 Dec 20;492(7429):S50-1. (PMID: 23254970)
      J Allergy Clin Immunol. 2022 Nov;150(5):1011-1030. (PMID: 35981904)
      Front Immunol. 2018 Sep 26;9:2167. (PMID: 30319628)
      Genet Mol Biol. 2022 Nov 07;45(4):e20220099. (PMID: 36382932)
      Am J Hum Genet. 2012 Jul 13;91(1):163-70. (PMID: 22703878)
      J Invest Dermatol. 2017 Mar;137(3):569-575. (PMID: 27939769)
      J Autoimmun. 2017 Mar;78:29-38. (PMID: 27965059)
      Nat Commun. 2018 Oct 2;9(1):4041. (PMID: 30279415)
      Cell Res. 2011 Jan;21(1):55-70. (PMID: 21187856)
      Medicine (Baltimore). 2022 Oct 7;101(40):e30890. (PMID: 36221432)
      Cell Immunol. 2020 Aug;354:104147. (PMID: 32593012)
      Nature. 2012 Dec 20;492(7429):S56-7. (PMID: 23254973)
      J Invest Dermatol. 2012 Jan;132(1):246-9. (PMID: 21850022)
      Am J Hum Genet. 2012 May 4;90(5):796-808. (PMID: 22521419)
      PLoS One. 2014 Nov 04;9(11):e111255. (PMID: 25369198)
      Pharmacogenet Genomics. 2016 Sep;26(9):423-7. (PMID: 27348478)
      J Invest Dermatol. 2013 Feb;133(2):377-85. (PMID: 23014338)
      Annu Rev Pathol. 2012;7:385-422. (PMID: 22054142)
      Am J Hum Genet. 2012 May 4;90(5):784-95. (PMID: 22521418)
      Nat Commun. 2015 May 05;6:7001. (PMID: 25939698)
      Int J Mol Sci. 2022 Apr 28;23(9):. (PMID: 35563264)
      Ann Rheum Dis. 2005 Mar;64 Suppl 2:ii18-23; discussion ii24-5. (PMID: 15708928)
      Mol Cancer. 2013 Aug 02;12:86. (PMID: 23915189)
      Int J Mol Sci. 2019 Mar 23;20(6):. (PMID: 30909615)
    • Contributed Indexing:
      Keywords: CARD14; Genetic triggers; Keratinocytes; NF-kB signaling pathway; PSORS2
    • Accession Number:
      0 (CARD Signaling Adaptor Proteins)
      EC 4.6.1.- (CARD14 protein, human)
      EC 4.6.1.2 (Guanylate Cyclase)
      0 (Membrane Proteins)
    • Publication Date:
      Date Created: 20241120 Date Completed: 20241120 Latest Revision: 20241125
    • Publication Date:
      20250114
    • Accession Number:
      PMC11579362
    • Accession Number:
      10.1038/s41598-024-78267-9
    • Accession Number:
      39567556