Association of dietary live microbes and nondietary prebiotic/probiotic intake with metabolic syndrome in US adults: evidence from NHANES.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Metabolic Syndrome*/epidemiology ; Probiotics*/administration & dosage ; Prebiotics*/administration & dosage ; Nutrition Surveys*; Humans ; Male ; Female ; Middle Aged ; Adult ; United States/epidemiology ; Prevalence ; Diet ; Aged

Background: Metabolic syndrome (MetS) presents substantial health risks, and the supplementation of probiotics and prebiotics is regarded as a promising management approach. This study aims to explore the relationship between dietary intake of live microbes and non-dietary prebiotic/probiotic intake and MetS among US adults.
Methods: Data from the National Health and Nutrition Examination Survey 1999-2016 was used in this study. MetS is defined according to the criteria set by the National Cholesterol Education Program-Adult Treatment Panel III-2005. Dietary intake information and probiotic/prebiotic intake data were collected through self-reported questionnaires. Multiple logistic models were applied to explore the relationships between dietary live microbes, and probiotic or prebiotic intake with MetS.
Results: A significantly lower prevalence of MetS was observed in individuals with a high intake of dietary live microbes compared to those with a low intake (OR: 0.79, 95% CI: 0.69-0.91). This association was particularly strong among participants with higher economic status and advanced educational attainment (interaction P < 0.05). Similarly, individuals with non-dietary probiotics intake displayed a similar trend (OR: 0.70, 95% CI: 0.54-0.92). Conversely, there was no significant association found between non-dietary prebiotic intake and MetS.
Conclusions: Dietary live microbes intake and non-dietary probiotic intake were negatively associated with the prevalence of MetS and its components. The study offers novel evidence supporting the effective management of MetS.
Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Ethics statement: The National Center for Health Statistics Research Ethics Review Committee reviewed and approved the NHANES study protocol. All participants signed written informed consent.
(© 2024. The Author(s).)

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Keywords: Dietary live microbes; Metabolic syndrome; National Health and Nutrition Examination Survey; Nondietary prebiotic; Nondietary probiotic

0 (Prebiotics)

Date Created: 20241231 Date Completed: 20241231 Latest Revision: 20250104

20250104

PMC11685591

10.1038/s41598-024-83971-7

39738746