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Facile universal strategy of presenting multifunctional short peptides for customizing desired surfaces.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, 2003-
    • Subject Terms:
      Polyphenols*/chemistry ; Peptides*/chemistry ; Surface Properties*; Hydrophobic and Hydrophilic Interactions ; Molecular Dynamics Simulation ; Biocompatible Materials/chemistry ; Humans ; Cell Adhesion/drug effects ; Cell Proliferation/drug effects ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Animals ; Static Electricity
    • Abstract:
      Competing Interests: Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: All authors are agreed to publish this paper. Competing interests: The authors declare no competing interests.
      Interfacial properties determine biomaterial performances, such as cell adhesion, signal exchange, and biomineralization, which affect the tissue repair cycle and efficiency of clinical applications. Peptides, as short protein sequences that have defined functionalities, are highly stable and easy to synthesize and have enormous potential to reshape interfacial properties. However, the lack of a universal strategy for presenting peptides on various substrates substantially hinders the application of peptides. In this study, we report a facile and universal strategy for customizing desired interfacial functionalities by a well-known layer-by-layer (LbL) technique through the assembly polyphenols with positively charged short peptide-coupling functional sequences. Polyphenol-peptide interactions were elucidated in detail by assembling polyphenols and peptides possessing different characteristics (charged, uncharged, hydrophobic, and sequence length) in combination with molecular dynamics simulations, and isothermal titration calorimetry further revealed the favorable enthalpy change due to electrostatic interactions is the main driving force for assembling peptides with polyphenols. LbL coatings assembled from polyphenols and positively charged peptides exhibited good substrate generalization, stability, cell proliferation, and antioxidant properties, when prepared as hollow capsules by sacrificing the template, exhibited significant pH and ultrasound stimulation responses, which could be suitable candidates for drug carriers. Most importantly, the LbL assembly strategy of positively charged peptides could be utilized to present various functional molecules (such as arginyl-glycyl-aspartic acid (RGD), a cell adhesion motif; CM15, an antibacterial peptide; and PEG, an antifouling surface) on various substrates for customizing desired surfaces. This study not only provides new insights into the understanding and regulation of interactions between proteins/peptides and polyphenols but also paves the way toward the interfacial functionalization of biomaterials.
      (© 2024. The Author(s).)
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    • Grant Information:
      WIUCASQD2021043 startup funding from the Wenzhou Institute of UCAS; WIUCASQD2019009 startup funding from the Wenzhou Institute of UCAS; 2022KY446 Zhejiang Provincial Program for Medicine and Health; 21ywb118 Social Development Science and Technology Foundation of Taizhou; 2020S0180083 Social Development Science and Technology Foundation of Wenling
    • Contributed Indexing:
      Keywords: Customized coating; Layer-by-layer assembly; Peptide; Polyphenol
    • Accession Number:
      0 (Polyphenols)
      0 (Peptides)
      0 (Biocompatible Materials)
      0 (Antioxidants)
    • Publication Date:
      Date Created: 20250101 Date Completed: 20250102 Latest Revision: 20250104
    • Publication Date:
      20250114
    • Accession Number:
      PMC11694446
    • Accession Number:
      10.1186/s12951-024-03041-y
    • Accession Number:
      39743532