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Sensation is dispensable for the maturation of the vestibulo-ocular reflex.

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  • Additional Information
    • Source:
      Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
    • Publication Information:
      Publication: : Washington, DC : American Association for the Advancement of Science
      Original Publication: New York, N.Y. : [s.n.] 1880-
    • Subject Terms:
      Motor Neurons*/physiology ; Reflex, Vestibulo-Ocular*/physiology ; Zebrafish*/physiology; Animals ; Eye Movements/physiology ; Feedback, Sensory ; Larva/physiology ; Neuromuscular Junction/physiology ; Oculomotor Muscles/physiology ; Oculomotor Muscles/innervation
    • Abstract:
      Vertebrates stabilize gaze using a neural circuit that transforms sensed instability into compensatory counterrotation of the eyes. Sensory feedback tunes this vestibulo-ocular reflex throughout life. We studied the functional development of vestibulo-ocular reflex circuit components in the larval zebrafish, with and without sensation. Blind fish stabilize gaze normally, and neural responses to body tilts mature before behavior. In contrast, synapses between motor neurons and the eye muscles mature with a time course similar to behavioral maturation. Larvae without vestibular sensory experience, but with mature neuromuscular junctions, had a strong vestibulo-ocular reflex. Development of the neuromuscular junction, and not sensory experience, therefore determines the rate of maturation of an ancient behavior.
    • Comments:
      Update of: bioRxiv. 2024 Sep 15:2024.05.17.594732. doi: 10.1101/2024.05.17.594732. (PMID: 38798369)
    • Publication Date:
      Date Created: 20250102 Date Completed: 20250102 Latest Revision: 20250107
    • Publication Date:
      20250114
    • Accession Number:
      10.1126/science.adr9982
    • Accession Number:
      39745953