Royal jelly reduced non-rapid eye movement sleep fragmentation and restored sleep stability in diet-induced obese mice.

Publisher: Japanese Association for Laboratory Animal Science Country of Publication: Japan NLM ID: 9604830 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-7122 (Electronic) Linking ISSN: 00075124 NLM ISO Abbreviation: Exp Anim Subsets: MEDLINE

Original Publication: Tokyo : Japanese Association for Laboratory Animal Science

Diet, High-Fat*/adverse effects ; Fatty Acids*/pharmacology ; Fatty Acids*/administration & dosage ; Obesity*/etiology ; Obesity*/drug therapy ; Dietary Supplements* ; Sleep Deprivation*/drug therapy ; Sleep Deprivation*/etiology ; Sleep*/drug effects; Animals ; Mice, Inbred C57BL ; Male ; Mice ; Mice, Obese ; Wakefulness/drug effects

Royal jelly (RJ) is recognized due to its high nutritional value and potential health benefits. Previous research showed that RJ supplementation decreased fat accumulation, resulting in weight loss and improvements in hyperglycemia and insulin resistance in high-fat diet (HFD)-induced obese mice. To expand the weight-reducing properties of RJ, this study aimed to investigate the effects of RJ supplementation on HFD-induced obese mice with impaired sleep stabilization. Over a 20-week period, the C57BL/6J mice were divided into the following dietary groups: normal diet (ND), ND supplemented with 5% lyophilized RJ powder (ND+RJ), HFD, and HFD supplemented with 5% lyophilized RJ powder (HFD+RJ) groups. Compared with the HFD group, the HFD+RJ group exhibited a significant reduction in body weight via a decrease in fat mass. Moreover, much like the ND group, the HFD+RJ group demonstrated improvements in the fragmentation of non-rapid eye movement (NREM) sleep and wakefulness. These processes contributed to the reestablishment of sleep/wake continuity and restored the overall stability of sleep. In contrast, the ND+RJ and ND groups exhibited a similar sleep/wake architecture. Thus, RJ supplementation in the ND demonstrated no substantial effect on sleep/wake. According to these findings, dietary RJ improves the sleep/wake architecture and restores sleep stability. Hence, RJ is a promising dietary component for addressing obesity and restoring sleep stability.

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Keywords: high-fat diet; non-rapid eye movement sleep; obesity; royal jelly; sleep stabilization

L497I37F0C (royal jelly)
0 (Fatty Acids)

Date Created: 20250113 Date Completed: 20250420 Latest Revision: 20250503

20250503

PMC12044360

10.1538/expanim.24-0128

39805626