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Description of two cases of follicular dendritic cell sarcoma, including next-generation sequencing analysis.

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  • Author(s): Jing Y;Jing Y;Jing Y; Ye H; Ye H; Luo S; Luo S; Wang J; Wang J
  • Source:
    Diagnostic pathology [Diagn Pathol] 2025 Feb 15; Vol. 20 (1), pp. 19. Date of Electronic Publication: 2025 Feb 15.
  • Publication Type:
    Journal Article; Case Reports
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101251558 Publication Model: Electronic Cited Medium: Internet ISSN: 1746-1596 (Electronic) Linking ISSN: 17461596 NLM ISO Abbreviation: Diagn Pathol Subsets: MEDLINE
    • Publication Information:
      Original Publication: [London] : BioMed Central, 2006-
    • Subject Terms:
      Dendritic Cell Sarcoma, Follicular*/genetics ; Dendritic Cell Sarcoma, Follicular*/pathology ; Dendritic Cell Sarcoma, Follicular*/diagnosis ; High-Throughput Nucleotide Sequencing*; Humans ; Male ; Female ; Middle Aged ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/analysis ; Adult ; Gene Rearrangement ; Diagnosis, Differential ; Immunohistochemistry
    • Abstract:
      Follicular dendritic cell sarcoma (FDCS), an infrequent malignancy, poses diagnostic challenges due to its nonspecific clinical presentations and propensity for recurrence and metastasis, particularly when assessed through imaging modalities. Accurate diagnosis relies heavily on pathological morphology and immunohistochemical analysis. This study examines two FDCS cases from the Affiliated Hospital of Zunyi Medical University. Next-generation sequencing (NGS) identified three gene rearrangements-HFM1::BIRC3, ELF4::AIFM1, and DIP2B::WIF1 -in one case, while no genetic alterations were detected in the other. The report explores clinicopathological characteristics, molecular genetics, differential diagnosis, therapeutic approaches, and prognosis to enhance diagnostic and pathological understanding of FDCS in medical practice.
      Competing Interests: Declarations. Ethics approval and consent to participate: Ethics approval was granted by the Ethics Committee of the Affiliated Hospital of Zunyi Medical University. Written informed consent for the publication of this clinical case report was obtained from the patients and their families. Consent for publication: Written informed consent was obtained from the patients and their families for the publication of this case report, including any associated images. Competing interests: The authors declare no competing interests.
      (© 2025. The Author(s).)
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    • Contributed Indexing:
      Keywords: Differential diagnosis; Follicular dendritic cell sarcoma; Next-generation sequencing; Pathology; Treatment
    • Accession Number:
      0 (Biomarkers, Tumor)
    • Publication Date:
      Date Created: 20250215 Date Completed: 20250215 Latest Revision: 20250218
    • Publication Date:
      20250218
    • Accession Number:
      PMC11829389
    • Accession Number:
      10.1186/s13000-025-01614-5
    • Accession Number:
      39955540