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Diagnostic value of neutrophil to lymphocyte ratio in identifying gastritis in children with chronic abdominal pain in northern Iran.

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  • Additional Information
    • Source:
      Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500 (Electronic) Linking ISSN: 17560500 NLM ISO Abbreviation: BMC Res Notes Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Biomed Central, 2008.
    • Subject Terms:
      Gastritis*/diagnosis ; Gastritis*/blood ; Gastritis*/microbiology ; Gastritis*/complications ; Abdominal Pain*/blood ; Abdominal Pain*/diagnosis ; Helicobacter Infections*/diagnosis ; Helicobacter Infections*/blood ; Helicobacter Infections*/microbiology ; Neutrophils* ; Lymphocytes*; Helicobacter pylori/isolation & purification ; Humans ; Male ; Child ; Female ; Iran ; Cross-Sectional Studies ; Adolescent ; Sensitivity and Specificity ; Lymphocyte Count ; Child, Preschool
    • Abstract:
      Background: This study aimed to assess the diagnostic value of the Neutrophil to Lymphocyte Ratio (NLR) specifically for children with suspected gastritis.
      Methods: This cross-sectional study included children with chronic abdominal pain referred to Amirkola Children's Hospital, Babol, Iran, in 2021. Gastritis was diagnosed using upper gastrointestinal endoscopy and biopsy, Giemsa staining performed for Helicobacter pylori. Blood samples were analyzed to determine the NLR. Analysis was employed to establish the optimal NLR cut-off for diagnosing gastritis, with sensitivity, specificity, and predictive values calculated.
      Results: 126 patients with an average age of 10.03 ± 2.46 were included in this study. 53.2% of children were boys The overall sensitivity and specificity of the mean NLR in diagnosing gastritis in children with abdominal pain based on endoscopy were 11.76% and 97.56%, respectively and for pathology 78.57% and 11.90%, respectively (Area under curve = 0.524 for endoscopy and 0.509 for pathology).
      Conclusion: This study indicate that the NLR lacks sufficient diagnostic accuracy to serve as a reliable alternative to conventional methods, such as endoscopy and pathology, for diagnosing gastritis or H. Pylori in children with chronic abdominal pain. Standard diagnostic techniques are needed for accurate evaluation and management of Helicobacter pylori-associated gastritis.
      (© 2025. The Author(s).)
    • Abstract:
      Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical standards of the Declaration of Helsinki. And all ethical considerations have been carefully observed. The research plan was conducted after receiving confirmation from the Ethics Committee of Babol University of Medical Sciences (IR.MUBABOL.HRI.REC.1402.043). Also, a letter of introduction was received from the director of the sampling locations to enhance the sampling process. The information of the study samples was kept confidential and all scientific sources were used in strict compliance with ethical principles. Finally, informed consent was obtained from the children’s parents for endoscopy and blood sampling to check CBC. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Conflict of interest: There was no conflict of interest.
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    • Contributed Indexing:
      Keywords: Children; Chronic abdominal pain; Gastritis; Neutrophil-to-lymphocyte ratio
    • Publication Date:
      Date Created: 20250215 Date Completed: 20250507 Latest Revision: 20250507
    • Publication Date:
      20260130
    • Accession Number:
      PMC11830187
    • Accession Number:
      10.1186/s13104-025-07148-9
    • Accession Number:
      39955609