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Change in D3Cr muscle mass in oldest old men and its association with changes in grip strength and walking speed.

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  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Hand Strength*/physiology ; Walking Speed*/physiology ; Muscle, Skeletal*/physiology; Humans ; Male ; Aged, 80 and over
    • Abstract:
      Competing Interests: I have read the journal's policy and the authors of this manuscript have the following competing interests: PMC and WJE are consultants and own stock in Myo Corps. . This does not alter our adherence to PLOS ONE policies on sharing data and materials.
      Background: The use of lean soft tissue (LST) mass as a surrogate measurement of skeletal muscle mass (SMM) has led to the conclusion that muscle loss is poorly related to functional decline. We hypothesized that when using a more accurate measure of SMM determined by D3-creatine dilution (D3Cr), longitudinal changes in SMM will be similar in magnitude to changes in strength and physical performance and that skeletal muscle mass will partially mediate the relationship of age with these outcomes.
      Methods: We measured change in D3Cr muscle mass (kg), handgrip strength (kg), and 6m walk speed (m/s) in 208 men from the Osteoporotic Fractures in Men Study (85.2 ± 4.3 years) over an average of 6.1 years follow-up. Mixed linear effects models adjusted for potential confounders were used to examine the relationship of changes in D3Cr muscle mass with changes in grip strength and walking speed.
      Results: Annual losses of D3Cr muscle mass, grip strength, and walking speed were 2.1%, 2.2%, and 2.6%, respectively (p < 0.001). Each additional kg loss in D3Cr muscle mass was associated with a 0.55 kg loss in grip strength and a 0.01 m/s loss in walking speed independent of changes in age (p < 0.001). 41.3% and 22.4% of the relationship between age and loss of grip strength and walking speed, respectively, was attributed to loss of D3Cr muscle mass (p < 0.001).
      Conclusion: Skeletal muscle mass may have a more important role than previously considered and should not be overlooked as a potentially modifiable determinant in the loss of strength and performance in older age.
      (Copyright: © 2025 Hetherington-Rauth et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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    • Grant Information:
      UL1 TR002369 United States TR NCATS NIH HHS; U01 AG042145 United States AG NIA NIH HHS; U01 AG042168 United States AG NIA NIH HHS; U01 AG042140 United States AG NIA NIH HHS; U01 AG027810 United States AG NIA NIH HHS; U01 AG042143 United States AG NIA NIH HHS; U01 AG042139 United States AG NIA NIH HHS; U01 AR066160 United States AR NIAMS NIH HHS; R01 AG066671 United States AG NIA NIH HHS; U01 AG042124 United States AG NIA NIH HHS
    • Publication Date:
      Date Created: 20250401 Date Completed: 20250515 Latest Revision: 20250515
    • Publication Date:
      20250519
    • Accession Number:
      PMC11960989
    • Accession Number:
      10.1371/journal.pone.0320752
    • Accession Number:
      40168350