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Comparative diagnostic efficacy and safety of ultrasound-guided percutaneous transhepatic biopsy and endoscopic ultrasound-guided fine-needle aspiration biopsy for gallbladder tumors.

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • Subject Terms:
      Gallbladder Neoplasms*/pathology ; Gallbladder Neoplasms*/diagnosis ; Gallbladder Neoplasms*/diagnostic imaging ; Endoscopic Ultrasound-Guided Fine Needle Aspiration*/methods ; Endoscopic Ultrasound-Guided Fine Needle Aspiration*/adverse effects ; Image-Guided Biopsy*/methods ; Image-Guided Biopsy*/adverse effects; Humans ; Female ; Male ; Middle Aged ; Aged ; Retrospective Studies ; Gallbladder/pathology ; Gallbladder/diagnostic imaging ; Aged, 80 and over ; Adult
    • Abstract:
      Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
      The objective of this study was to compare the diagnostic efficacy and safety of ultrasound-guided percutaneous transhepatic gallbladder biopsy (PTGB) with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in the assessment of gallbladder tumors. We conducted a retrospective, single-center study involving 101 patients diagnosed with gallbladder cancer who underwent either PTGB or EUS-FNA between January 2019 and December 2022. The study cohort was divided into two groups: 52 patients underwent PTGB, and 49 underwent EUS-FNA. Clinical data, diagnostic outcomes, patient demographics, and complications were systematically documented. The sensitivity, accuracy, and incidence of complications were evaluated for both groups. The sensitivity and accuracy rates were 94.23% and 94.23% for PTGB compared to 97.82% and 97.96% for EUS-FNA, with no significant difference between the two techniques. However, EUS-FNA was associated with significantly lower rate of adverse reactions (2.04%) compared to PTGB (15.38%). Both PTGB and EUS-FNA exhibited high diagnostic efficacy for gallbladder tumors. However, EUS-FNA demonstrated a significantly lower incidence of complications, making it a compelling alternative to PTGB, especially when percutaneous biopsy is unsuccessful or not feasible. High-quality prospective, multicenter trials are recommended to further validate these findings and to refine biopsy guidelines for gallbladder tumors.
      (© 2025. The Author(s).)
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    • Contributed Indexing:
      Keywords: Biopsy; Diagnostic accuracy; Endoscopic ultrasound; Gallbladder cancer; Percutaneous
    • Publication Date:
      Date Created: 20250409 Date Completed: 20250409 Latest Revision: 20250412
    • Publication Date:
      20250414
    • Accession Number:
      PMC11982247
    • Accession Number:
      10.1038/s41598-025-87847-2
    • Accession Number:
      40204763