Antisenescence therapies for age-related bone loss: Target factors, medicines, biomedical materials.

Publisher: Wiley Country of Publication: United States NLM ID: 101597971 Publication Model: Print Cited Medium: Internet ISSN: 2001-1326 (Electronic) Linking ISSN: 20011326 NLM ISO Abbreviation: Clin Transl Med Subsets: MEDLINE

Publication: 2020- : [Hoboken, NJ] : Wiley
Original Publication: Heidelberg : Springer-Verlag

Aging*/physiology ; Cellular Senescence*/drug effects ; Cellular Senescence*/physiology ; Osteoporosis*/drug therapy; Humans ; Bone and Bones ; Animals

Progress in living conditions and medical technology have extended the human life span such that population aging, and thus the development of multi-system degenerative diseases, has become a major problem in many countries. Bone is a metabolically dynamic tissue and bone aging is closely related to a shift in the balance between bone resorption and bone formation. The resulting loss of bone mass and bone mechanical properties in older adults place them at risk of injury and premature death. Cellular senescence occurs in response to endogenous and exogenous stresses that lead to permanent cell cycle arrest and, thus, to tissue degeneration and dysfunction. Senescence in the bone microenvironment, as occurs during aging, induces a decline in bone formation. Research into the treatment of bone aging has therefore focused on the senescence process. This review begins with a summary of the key events in cellular senescence and bone aging and then examines recent progress in the targeting of cellular senescence, both to treat aging-related bone diseases. Novel therapeutic agents, natural products, and innovative biomedical materials are considered. Our discussion concludes by considering areas of future research.
(© 2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.)

Front Pharmacol. 2023 Jan 20;14:1083875. (PMID: 36744254)
Signal Transduct Target Ther. 2021 Apr 7;6(1):143. (PMID: 33824289)
Tissue Eng Part A. 2014 Mar;20(5-6):992-1002. (PMID: 24195838)
ACS Biomater Sci Eng. 2023 May 8;9(5):2636-2646. (PMID: 37036053)
J Ethnopharmacol. 2017 Feb 23;198:64-72. (PMID: 28040510)
JBMR Plus. 2023 Apr 18;7(6):e10745. (PMID: 37283656)
Front Endocrinol (Lausanne). 2024 Apr 04;15:1360054. (PMID: 38638133)
J Cell Physiol. 2018 May;233(5):4194-4204. (PMID: 29030963)
Biochem Pharmacol. 2021 Oct;192:114676. (PMID: 34256044)
Food Funct. 2024 Nov 25;15(23):11686-11696. (PMID: 39530768)
Bone. 2019 Apr;121:121-133. (PMID: 30659978)
Nat Rev Endocrinol. 2020 May;16(5):263-275. (PMID: 32161396)
Cell Death Differ. 2016 Jul;23(7):1128-39. (PMID: 26868907)
Cell. 2019 Oct 31;179(4):813-827. (PMID: 31675495)
Nat Commun. 2023 Nov 27;14(1):7783. (PMID: 38012166)
Metabolism. 2018 Nov;88:61-71. (PMID: 30318050)
EMBO J. 2023 May 2;42(9):e111762. (PMID: 36943004)
Stem Cell Res Ther. 2021 May 6;12(1):271. (PMID: 33957971)
Cell Death Discov. 2022 May 6;8(1):254. (PMID: 35523787)
Front Cell Dev Biol. 2020 May 20;8:354. (PMID: 32509782)
Bioact Mater. 2023 Nov 04;33:14-29. (PMID: 38024235)
Clin Transl Med. 2025 Jun;15(6):e70350. (PMID: 40490937)
Aging Dis. 2018 Dec 4;9(6):1103-1121. (PMID: 30574422)
Mech Ageing Dev. 2024 Oct;221:111976. (PMID: 39111640)
Nat Med. 2017 Sep;23(9):1072-1079. (PMID: 28825716)
Heliyon. 2023 Apr 03;9(4):e15188. (PMID: 37096002)
Aging Clin Exp Res. 2021 Apr;33(4):805-821. (PMID: 31595428)
Differentiation. 2015 Nov-Dec;90(4-5):91-100. (PMID: 26677981)
Antioxidants (Basel). 2022 Nov 23;11(12):. (PMID: 36552528)
Oxid Med Cell Longev. 2016;2016:9785890. (PMID: 27195075)
Int J Oral Sci. 2020 Feb 6;12(1):6. (PMID: 32024822)
Sci China Life Sci. 2022 Nov;65(11):2218-2232. (PMID: 35633481)
ACS Appl Mater Interfaces. 2022 Jan 26;14(3):3885-3899. (PMID: 35014784)
Adv Mater. 2024 Mar;36(9):e2306552. (PMID: 37848015)
Crit Rev Biochem Mol Biol. 2014 Jan-Feb;49(1):16-32. (PMID: 24164576)
Arch Gerontol Geriatr. 2021 Jan - Feb;92:104288. (PMID: 33147533)
Stem Cell Reports. 2017 Feb 14;8(2):387-400. (PMID: 28162996)
Mol Cell Endocrinol. 2022 Jan 1;539:111490. (PMID: 34655661)
Free Radic Biol Med. 2022 Jan;178:246-261. (PMID: 34890768)
Nat Med. 2015 Dec;21(12):1424-35. (PMID: 26646499)
Cell Discov. 2019 Mar 19;5:16. (PMID: 30911407)
Chin Med. 2019 Jul 15;14:24. (PMID: 31338119)
ACS Biomater Sci Eng. 2020 Dec 14;6(12):6874-6885. (PMID: 33320606)
Front Immunol. 2023 Feb 06;14:1114006. (PMID: 36814916)
Stem Cells. 2024 May 15;42(5):475-490. (PMID: 38427800)
Cell Tissue Res. 2021 Nov;386(2):297-308. (PMID: 34223980)
Theranostics. 2018 Mar 23;8(9):2387-2406. (PMID: 29721087)
Cell Death Dis. 2017 Feb 2;8(2):e2595. (PMID: 28151468)
Small. 2024 Mar;20(12):e2304433. (PMID: 37948437)
Mech Ageing Dev. 2018 Apr;171:1-6. (PMID: 29398003)
Nat Med. 2022 Aug;28(8):1556-1568. (PMID: 35953721)
Int J Mol Sci. 2023 Jan 28;24(3):. (PMID: 36768829)
Int J Mol Sci. 2022 Oct 19;23(20):. (PMID: 36293376)
Bone. 2020 Apr;133:115252. (PMID: 31978617)
Front Pharmacol. 2022 Jun 15;13:886198. (PMID: 35784750)
ACS Biomater Sci Eng. 2023 Aug 14;9(8):4720-4734. (PMID: 37491189)
Am J Transl Res. 2022 Jan 15;14(1):582-593. (PMID: 35173876)
Stem Cells Int. 2020 May 26;2020:2365814. (PMID: 32565825)
Int J Mol Sci. 2024 Aug 05;25(15):. (PMID: 39126105)
Aging Cell. 2018 Jun;17(3):e12741. (PMID: 29488314)
J Cell Physiol. 2023 Dec;238(12):2827-2840. (PMID: 37801347)
Am J Transl Res. 2020 Feb 15;12(2):672-683. (PMID: 32194914)
J Osteoporos. 2023 Feb 22;2023:5572754. (PMID: 36875869)
Adv Healthc Mater. 2024 Dec;13(30):e2401275. (PMID: 38979868)
Stem Cells Int. 2017;2017:6921703. (PMID: 29348759)
Biogerontology. 2021 Apr;22(2):165-187. (PMID: 33502634)
Tissue Eng Part A. 2017 Nov;23(21-22):1231-1240. (PMID: 28363268)
Front Cell Dev Biol. 2022 Oct 25;10:1031638. (PMID: 36393858)
J Bone Miner Res. 2020 Mar;35(3):583-595. (PMID: 31725940)
Aging Cell. 2022 Feb;21(2):e13551. (PMID: 35032339)
Aging Cell. 2021 Jul;20(7):e13394. (PMID: 34101970)
Clin Transl Med. 2022 Feb;12(2):e746. (PMID: 35220680)
Life Sci. 2020 Sep 15;257:118055. (PMID: 32634429)
J Clin Invest. 2018 Apr 2;128(4):1208-1216. (PMID: 29457783)
Stem Cell Res Ther. 2020 Nov 4;11(1):467. (PMID: 33148318)
Bioact Mater. 2022 Sep 21;21:547-565. (PMID: 36185749)
Cell Mol Biol Lett. 2023 Oct 27;28(1):88. (PMID: 37891477)
Annu Rev Physiol. 2013;75:685-705. (PMID: 23140366)
Cell Prolif. 2023 Oct;56(10):e13476. (PMID: 37042047)
Front Pharmacol. 2023 Mar 03;14:1067085. (PMID: 36937895)
J Cell Mol Med. 2020 Dec;24(23):13863-13875. (PMID: 33124763)
Adv Healthc Mater. 2023 Dec;12(30):e2301798. (PMID: 37667873)
Bone Joint Res. 2024 Feb 1;13(2):52-65. (PMID: 38295830)
J Bone Miner Res. 2024 Aug 5;39(7):994-1007. (PMID: 38843356)
Acta Biomater. 2023 Feb;157:352-366. (PMID: 36470392)
Cell Prolif. 2020 Apr;53(4):e12755. (PMID: 32154622)
J Periodontal Res. 2023 Dec;58(6):1300-1314. (PMID: 37715945)
Sci Rep. 2023 Nov 20;13(1):20314. (PMID: 37985890)
Mater Sci Eng C Mater Biol Appl. 2021 Jul;126:112145. (PMID: 34082956)
Oxid Med Cell Longev. 2022 Jan 18;2022:7420726. (PMID: 35087617)
Mayo Clin Proc. 2022 Jun;97(6):1194-1208. (PMID: 35662432)
Aging (Albany NY). 2020 Aug 3;12(16):15882-15905. (PMID: 32745074)
Drug Deliv Transl Res. 2017 Aug;7(4):466-481. (PMID: 28589453)
Int Immunopharmacol. 2023 Feb;115:109694. (PMID: 36638657)
J Endocrinol. 2020 Apr;245(1):141-153. (PMID: 32045363)
Nat Commun. 2017 Jan 17;8:14063. (PMID: 28094793)
Bone Res. 2024 Nov 20;12(1):66. (PMID: 39567500)
Biomed Pharmacother. 2017 May;89:1178-1186. (PMID: 28320084)
J Dent Res. 2019 Jul;98(7):795-802. (PMID: 31136719)
Acta Biomater. 2024 Mar 15;177:486-505. (PMID: 38311197)
Int J Mol Sci. 2024 Mar 03;25(5):. (PMID: 38474198)
Cell. 2013 Nov 21;155(5):1104-18. (PMID: 24238962)
ACS Nano. 2022 Sep 27;16(9):15397-15412. (PMID: 36106984)
Redox Rep. 2019 Dec;24(1):62-69. (PMID: 31438780)
Bioact Mater. 2022 Feb 05;18:15-25. (PMID: 35387160)
Aging Cell. 2024 Nov;23(11):e14293. (PMID: 39123275)
Bioact Mater. 2023 Jan 20;25:13-28. (PMID: 37056256)
Nat Rev Mol Cell Biol. 2021 Feb;22(2):75-95. (PMID: 33328614)
Exp Cell Res. 1961 Dec;25:585-621. (PMID: 13905658)
NPJ Regen Med. 2021 Jun 11;6(1):34. (PMID: 34117259)
Cell Rep Med. 2024 Aug 20;5(8):101665. (PMID: 39168101)
Stem Cell Rev Rep. 2024 Feb;20(2):554-567. (PMID: 38150082)
Am J Transl Res. 2023 Mar 15;15(3):2220-2232. (PMID: 37056849)
Curr Osteoporos Rep. 2020 Oct;18(5):559-567. (PMID: 32794138)

82370924 National Natural Science Foundation of China; 82170929 National Natural Science Foundation of China; L222090 Beijing Natural Science Foundation; L222145 Beijing Natural Science Foundation; 2021J01803 Fujian Province Natural Science Foundation of China

Keywords: biomedical materials; bone aging; cellular senescence; medicines; target factors

Date Created: 20250610 Date Completed: 20250610 Latest Revision: 20250612

20250612

PMC12148957

10.1002/ctm2.70350

40490937