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Tight junction proteins and intestinal health in preterm infants.

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  • Additional Information
    • Source:
      Publisher: SAGE Publications Country of Publication: United States NLM ID: 101468335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4429 (Electronic) Linking ISSN: 18784429 NLM ISO Abbreviation: J Neonatal Perinatal Med Subsets: MEDLINE
    • Publication Information:
      Publication: 2024- : [Thousand Oaks, CA] : SAGE Publications
      Original Publication: Amsterdam : IOS Press, 2008-
    • Subject Terms:
      Enterocolitis, Necrotizing*/metabolism ; Enterocolitis, Necrotizing*/physiopathology ; Enterocolitis, Necrotizing*/diagnosis ; Intestinal Mucosa*/metabolism ; Tight Junction Proteins*/metabolism ; Tight Junctions*/metabolism ; Infant, Premature*; Biomarkers/metabolism ; Humans ; Infant, Newborn
    • Abstract:
      The intestinal epithelial barrier consists of a single layer of cells that separate the gut lumen from the rest of the body. It regulates and protects the intestinal tract immunologically and mechanically. Necrotizing enterocolitis (NEC) is one of the most common conditions requiring emergency surgery in the neonatal intensive care unit and is associated with a septic shock-like state contributing to multi-organ dysfunction. NEC affects 6-10% of very low birthweight infants and remains a leading cause of death. This review presents current evidence of the role of tight junction (TJ) proteins in clinical neonatology and intestinal health using information from our own clinical and laboratory research in conjunction with information collected from an extensive search in the databases PubMed, EMBASE, and Scopus. The ability to measure the permeability of the intestinal barrier in real-time is essential to understanding the disease process of NEC and the subsequent morbidities. Detection of TJ proteins in blood and stool of preterm infants represents a potential biomarker for the early NEC diagnosis. Therapeutics targeting TJ proteins may also mitigate NEC severity and improve clinical outcomes.
    • Abstract:
      Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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    • Grant Information:
      U54 GM115428 United States GM NIGMS NIH HHS
    • Contributed Indexing:
      Keywords: NEC; anemia; claudins; necrotizing enterocolitis; preterm infant; tight junction proteins
    • Accession Number:
      0 (Tight Junction Proteins)
      0 (Biomarkers)
    • Publication Date:
      Date Created: 20250616 Date Completed: 20250905 Latest Revision: 20250907
    • Publication Date:
      20260130
    • Accession Number:
      PMC12226259
    • Accession Number:
      10.1177/19345798251349394
    • Accession Number:
      40521896