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The diagnostic value of MRI-PDFF in hepatic steatosis of patients with metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis.

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  • Author(s): Zhang YX;Zhang YX; Feng YP; Feng YP; You CL; You CL; Zhang LY; Zhang LY
  • Source:
    BMC gastroenterology [BMC Gastroenterol] 2025 Jul 01; Vol. 25 (1), pp. 451. Date of Electronic Publication: 2025 Jul 01.
  • Publication Type:
    Journal Article; Systematic Review; Meta-Analysis
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2001-
    • Subject Terms:
      Magnetic Resonance Imaging*/methods ; Fatty Liver*/diagnostic imaging ; Fatty Liver*/pathology ; Fatty Liver*/etiology ; Non-alcoholic Fatty Liver Disease*/diagnostic imaging; Humans ; Sensitivity and Specificity ; Liver/pathology ; Liver/diagnostic imaging ; Biopsy
    • Abstract:
      Competing Interests: Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
      Objective: To evaluate the diagnostic efficacy of magnetic resonance imaging proton density fat fraction (MRI-PDFF) in assessing hepatic steatosis among patients with metabolic dysfunction-associated steatotic liver disease (MASLD) through systematic review and meta-analysis approaches.
      Methods: Comprehensive searches were conducted across major public electronic databases, including PubMed, Web of Science, Cochrane Library, and Embase, to identify relevant studies that compared MRI-PDFF with liver biopsy in diagnosing steatosis in MASLD patients. Diagnostic accuracy was assessed using sensitivity, specificity, and the area under the curve (AUC) for differentiating various steatosis grades (S0 vs. S1-3; S0-1 vs. S2-3; S0-2 vs. S3).
      Results: A total of 10 studies involving 939 MASLD patients were included in this meta-analysis. MRI-PDFF demonstrated robust diagnostic performance for steatosis grading, with sensitivity values ranging from 0.77 to 0.92 and specificity from 0.87 to 0.94. The AUC values were 0.98 (95% CI: 0.96-0.99) for S0 vs. S1-3, 0.92 (95% CI: 0.89-0.94) for S0-1 vs. S2-3, and 0.90 (95% CI: 0.87-0.93) for S0-2 vs. S3.
      Conclusion: This meta-analysis suggests that MRI-PDFF is highly effective in grading steatosis in MASLD patients. Further validation through additional high-quality studies is warranted to consolidate these findings.
      Clinical Trial Number: Not applicable.
      (© 2025. The Author(s).)
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    • Contributed Indexing:
      Keywords: Diagnosis; MRI-PDFF; Meta-analysis; Nonalcoholic fatty liver disease; Steatosis
    • Publication Date:
      Date Created: 20250702 Date Completed: 20250702 Latest Revision: 20250715
    • Publication Date:
      20250717
    • Accession Number:
      PMC12210736
    • Accession Number:
      10.1186/s12876-025-04017-4
    • Accession Number:
      40596891