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Venovenous extracorporeal membrane oxygenation in severe community-acquired Acinetobacter baumannii pneumonia.

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  • Author(s): Jiang L;Jiang L; Zhou L; Zhou L; Huang S; Huang S; Ao Z; Ao Z; Han X; Han X
  • Source:
    Journal of infection in developing countries [J Infect Dev Ctries] 2025 Jun 30; Vol. 19 (6), pp. 971-976. Date of Electronic Publication: 2025 Jun 30.
  • Publication Type:
    Journal Article; Case Reports
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Open Learning on Enteric Pathogens Country of Publication: Italy NLM ID: 101305410 Publication Model: Electronic Cited Medium: Internet ISSN: 1972-2680 (Electronic) Linking ISSN: 19722680 NLM ISO Abbreviation: J Infect Dev Ctries Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Italy?] : Open Learning on Enteric Pathogens
    • Subject Terms:
      Extracorporeal Membrane Oxygenation*/methods ; Acinetobacter baumannii*/isolation & purification ; Community-Acquired Infections*/therapy ; Community-Acquired Infections*/microbiology ; Community-Acquired Infections*/diagnosis ; Acinetobacter Infections*/therapy ; Acinetobacter Infections*/diagnosis ; Acinetobacter Infections*/microbiology ; Pneumonia, Bacterial*/therapy ; Pneumonia, Bacterial*/diagnosis ; Pneumonia, Bacterial*/microbiology; Humans ; Male ; Middle Aged ; Anti-Bacterial Agents/therapeutic use ; Treatment Outcome ; Respiratory Distress Syndrome/therapy ; Meropenem/therapeutic use ; Tigecycline
    • Abstract:
      Competing Interests: No Conflict of Interest is declared
      Introduction: Globally, Acinetobacter baumannii (A. baumannii) is a significant nosocomial pathogen. Community-acquired pneumonia (CAP) caused by A. baumannii is rare, but often associated with severe outcomes.
      Case Presentation: A 48-year-old man was admitted to a local hospital, presenting a 14-hour history of acute fever, cough, expectoration, chest pain, and dyspnea. Owing to the development of severe acute respiratory distress syndrome (ARDS) and septic shock, the patient was promptly transferred to our institution for veno-venous extracorporeal membrane oxygenation (VV-ECMO) following intubation and mechanical ventilation. Sputum culture, digital polymerase chain reaction (dPCR) assay of blood, and metagenomic next-generation sequencing (mNGS) assay of bronchoalveolar lavage fluid (BALF) all indicated A. baumannii. The patient responded favorably to treatment with meropenem and tigecycline. The amelioration of his respiratory function allowed for the cessation of ECMO after 7 days; and subsequently, the patient was successfully weaned from ventilatory support.
      Conclusions: A. baumannii should be considered as a possible causative organism of CAP based on presentation in the tropical or subtropical wet season, a very aggressive clinical course, typical chest imaging features, and the presence of A. baumannii in sputum. ECMO represents an efficacious treatment alternative for severe ARDS and septic shock complications associated with A. baumannii when conventional mechanical ventilation proves inadequate, particularly when initiated early in the clinical course.
      (Copyright (c) 2025 Lei Jiang, Lin Zhou, Shicong Huang, Zhi Ao, Xiaoli Han.)
    • Contributed Indexing:
      Keywords: Acinetobacter baumannii; ECMO; extracorporeal membrane oxygenation; pneumonia; septic shock
    • Accession Number:
      0 (Anti-Bacterial Agents)
      FV9J3JU8B1 (Meropenem)
      70JE2N95KR (Tigecycline)
    • Publication Date:
      Date Created: 20250703 Date Completed: 20250703 Latest Revision: 20250703
    • Publication Date:
      20250704
    • Accession Number:
      10.3855/jidc.19761
    • Accession Number:
      40608709