Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Association between post-stroke depressiveness and the utilization of healthcare services three months after the stroke.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • Subject Terms:
    • Abstract:
      Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Ethics approval: The study was conducted according to the Declaration of Helsinki. Ethical approval was granted by the Ethics Committee of the Ludwig-Maximilians-Universität München (Reference-Number: 18–196) in August 2018. Consent to participate: Written informed consent was obtained from all participants or legal caregivers.
      Post-stroke depression affects approximately one-third of stroke survivors and can result in various adverse outcomes. With the rising prevalence of strokes, understanding the impact of post-stroke depression on healthcare utilization is crucial. The study examined the association between patient-reported post-stroke depressiveness and the healthcare service utilization three months post-stroke. The prospective Stroke Cohort Augsburg (SCHANA) study assessed post-stroke depressiveness using the Patient Health Questionnaire (PHQ-9) during hospital stay. Participants reported their utilization of medical and therapeutic services, rehabilitation, and inpatient hospital stays three months post-discharge. Multivariable adjusted linear and binary logistic regression analyses examined the association between post-stroke depressiveness and healthcare service utilization. Among 546 participants included into the analyses, 57.1% had no depression, 28.8% had mild depression and 14.9% had moderate to severe depression. Higher PHQ-9 scores were associated with a significantly increased likelihood of inpatient hospital treatment (OR = 1.07; 95% CI: 1.01-1.14; p = 0.016), attendance at rehabilitation programs (OR = 1.09; 95% CI: 1.03-1.15; p = 0.003), and more frequent utilization of general practitioners/internists (beta = 0.10; 95% CI: 0.01-0.19; p = 0.036). In conclusion, post-stroke depressiveness was associated with increased healthcare service utilization. Further studies are required to gain a more comprehensive understanding.
      (© 2025. The Author(s).)
    • References:
      Robert Koch-Institut (RKI). Schlaganfall: Prävalenz. Available at https://www.gbe.rki.de/DE/Themen/Gesundheitszustand/KoerperlicheErkrankungen/HerzKreislaufErkrankungen/SchlaganfallPraevalenz/schlaganfallPraevalenz_node.html?darstellung=0&kennzahl=1&zeit=2014&geschlecht=0&standardisierung=0.
      Robert Koch-Institut (RKI). Schlaganfall: Sterblichkeit. Available at https://www.gbe.rki.de/DE/Themen/Gesundheitszustand/KoerperlicheErkrankungen/HerzKreislaufErkrankungen/SchlaganfallSterblichkeit/schlaganfallSterblichkeit_node.html?darstellung=0&kennzahl=1&zeit=2022&geschlecht=0&standardisierung=3.
      GBD 2016 Stroke Collaborators. Global, regional, and National burden of stroke, 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet Neurol. 18, 439–458 (2019).
      Strilciuc, S. et al. The economic burden of stroke: a systematic review of cost of illness studies. J. Med. Life. 14, 606–619 (2021). (PMID: 350279638742896)
      Weimar, C. et al. Kostenanalyse der schlaganfallbehandlung in Deutschland - Eine auswertung der Schlaganfalldatenbank der stiftung Deutsche Schlaganfall-Hilfe -. Akt. Neurol. 29, 181–190 (2002).
      Rajsic, S. et al. Economic burden of stroke: a systematic review on post-stroke care. Eur. J. Health Economics: HEPAC : Health Econ. Prev. Care. 20, 107–134 (2019).
      Stewart, C. E., Branyan, T. E., Sampath, D. & Sohrabji, F. Sex differences in the Long-Term consequences of stroke. Curr. Top. Behav. Neurosci. 62, 287–308 (2023). (PMID: 35332459)
      Das, J. Post stroke depression: the sequelae of cerebral stroke. Neurosci. Biobehav. Rev. 90, 104–114 (2018). (PMID: 29656030)
      Guo, J., Wang, J., Sun, W. & Liu, X. The advances of post-stroke depression: 2021 update (2022).
      Towfighi, A. et al. Poststroke depression: A scientific statement for healthcare professionals from the American heart association/american stroke association. Stroke 48, e30–e43 (2017). (PMID: 27932603)
      Medeiros, G. C., Roy, D., Kontos, N. & Beach, S. R. Post-stroke depression: A 2020 updated review. Gen. Hosp. Psychiatry. 66, 70–80 (2020). (PMID: 32717644)
      Ayerbe, L., Ayis, S., Wolfe, C. D. A. & Rudd, A. G. Natural history, predictors and outcomes of depression after stroke: systematic review and meta-analysis. Br. J. Psychiatry: J. Mental Sci. 202, 14–21 (2013).
      Liu, L. et al. Prevalence and natural history of depression after stroke: A systematic review and meta-analysis of observational studies. PLoS Med. 20, e1004200 (2023). (PMID: 3697679410047522)
      Dong, L., Mezuk, B., Williams, L. S. & Lisabeth, L. D. Trends in outpatient treatment for depression in survivors of stroke in the united states, 2004–2017. Neurology 98, e2258–e2267 (2022). (PMID: 353797569162167)
      Husaini, B. et al. Depression increases stroke hospitalization cost: an analysis of 17,010 stroke patients in 2008 by race and gender. Stroke research and treatment 846732 (2013). (2013).
      Ertl, M. et al. Long-Term outcomes in patients with stroke after in-Hospital Treatment-Study protocol of the prospective stroke cohort Augsburg (SCHANA Study). Medicina (Kaunas Lithuania) 56 (2020).
      Manea, L., Gilbody, S. & McMillan, D. A diagnostic meta-analysis of the patient health Questionnaire-9 (PHQ-9) algorithm scoring method as a screen for depression. Gen. Hosp. Psychiatry. 37, 67–75 (2015). (PMID: 25439733)
      Kroenke, K., Spitzer, R. L. & Williams, J. B. The PHQ-9: validity of a brief depression severity measure. J. Gen. Intern. Med. 16, 606–613 (2001). (PMID: 115569411495268)
      Mitchell, A. J., Yadegarfar, M., Gill, J. & Stubbs, B. Case finding and screening clinical utility of the patient health questionnaire (PHQ-9 and PHQ-2) for depression in primary care: a diagnostic meta-analysis of 40 studies. BJPsych Open. 2, 127–138 (2016). (PMID: 277037654995584)
      Oleg, N., Medvedev, C. U., Krägeloh, R. J. & Siegert Nirbhay N. Singh. Handbook of Assessment in Mindfulness Research (SPRINGER INTERNATIONAL PU, (2024).
      Löwe, B., Spitzer, R. L., Zipfel, S. & Herzog, W. PHQ-D Manual. Komplettversion und Kurzform. Autorisierte deutsche Version des „Prime MD Patient Health Questionnaire (PHQ). Available at https://www.klinikum.uni-heidelberg.de/fileadmin/Psychosomatische_Klinik/download/PHQ_Manual1.pdf.
      World Health Organization (WHO). Obesity: preventing and managing the global epidemdic. Report of a WHO Consultation. (2000). Available at https://iris.who.int/handle/10665/42330.
      Lyden, P. Using the National institutes of health stroke scale: A cautionary Tale. Stroke 48, 513–519 (2017). (PMID: 28077454)
      Lyden, P. et al. National institutes of health stroke scale certification is reliable across multiple venues. Stroke 40, 2507–2511 (2009). (PMID: 195209982726278)
      National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N. Engl. J. Med. 333, 1581–1587 (1995).
      Banks, J. L. & Marotta, C. A. Outcomes validity and reliability of the modified Rankin scale: implications for stroke clinical trials: a literature review and synthesis. Stroke 38, 1091–1096 (2007). (PMID: 17272767)
      Duncan, P. W. et al. The stroke impact scale version 2.0. Evaluation of reliability, validity, and sensitivity to change. Stroke 30, 2131–2140 (1999). (PMID: 10512918)
      Digitale, J. C., Martin, J. N. & Glymour, M. M. Tutorial on directed acyclic graphs. J. Clin. Epidemiol. 142, 264–267 (2022). (PMID: 34371103)
      Textor, J., van der Zander, B., Gilthorpe, M. S., Liskiewicz, M. & Ellison, G. T. Robust causal inference using directed acyclic graphs: the R package ‘dagitty’. Int. J. Epidemiol. 45, 1887–1894 (2016). (PMID: 28089956)
      Box, G. E. & Tidwell, P. W. Transformation of the independent variables. Technometrics 4, 531–550 (1962).
      Huber, P. J. Robust Statistics (Wiley, 1981).
      Hayes, A. F. & Cai, L. Using heteroskedasticity-consistent standard error estimators in OLS regression: an introduction and software implementation. Behav. Res. Methods. 39, 709–722 (2007). (PMID: 18183883)
      DeepL, S. E. DeepL Write. Available at https://www.deepl.com/de/write.
      Lundberg, J. et al. Association of Treatment-Resistant depression with patient outcomes and health care resource utilization in a Population-Wide study. JAMA Psychiatry. 80, 167–175 (2023). (PMID: 36515938)
      Tusa, N. et al. The profiles of health care utilization among a non-depressed population and patients with depressive symptoms with and without clinical depression. Scand. J. Prim. Health Care. 37, 312–318 (2019). (PMID: 313178106713190)
      Bock, J. O. et al. Impact of depression on health care utilization and costs among multimorbid patients–from the multicare cohort study. PloS One. 9, e91973 (2014). (PMID: 246380403956806)
      Luppa, M. et al. Health service utilization and costs of depressive symptoms in late life - a systematic review. Curr. Pharm. Design. 18, 5936–5957 (2012).
      Schlyter, M. et al. Personality factors and depression as predictors of hospital-based health care utilization following acute myocardial infarction. Eur. J. Cardiovasc. Nurs. 16, 318–325 (2017). (PMID: 27566599)
      Kassenärztlichen Bundesvereinigung. Versichertenbefragung der Kassenärztlichen Bundesvereinigung 2021 - Ergebnisse einer repräsentativen Bevölkerungsumfrage. (2021). Available at https://www.kbv.de/media/sp/2021_KBV-Versichertenbefragung_Berichtband.pdf.
      Ghose, S. S., Williams, L. S. & Swindle, R. W. Depression and other mental health diagnoses after stroke increase inpatient and outpatient medical utilization three years poststroke. Med. Care. 43, 1259–1264 (2005). (PMID: 16299438)
      Jia, H. et al. The impact of poststroke depression on healthcare use by veterans with acute stroke. Stroke 37, 2796–2801 (2006). (PMID: 17008625)
      Dossa, A., Glickman, M. E. & Berlowitz, D. Association between mental health conditions and rehospitalization, mortality, and functional outcomes in patients with stroke following inpatient rehabilitation. BMC Health Serv. Res. 11, 311 (2011). (PMID: 220857793280187)
      van Swieten, J. C., Koudstaal, P. J., Visser, M. C., Schouten, H. J. & van Gijn, J. Interobserver agreement for the assessment of handicap in stroke patients. Stroke 19, 604–607 (1988). (PMID: 3363593)
      Williams, L. S. et al. Performance of the PHQ-9 as a screening tool for depression after stroke. Stroke 36, 635–638 (2005). (PMID: 15677576)
      Tay, J., Morris, R. G. & Markus, H. S. Apathy after stroke: diagnosis, mechanisms, consequences, and treatment. Int. J. Stroke: Official J. Int. Stroke Soc. 16, 510–518 (2021).
      Carnes-Vendrell, A., Deus, J., Molina-Seguin, J., Pifarré, J. & Purroy, F. Depression and apathy after transient ischemic attack or minor stroke: prevalence, evolution and predictors. Sci. Rep. 9, 16248 (2019). (PMID: 317000586838079)
      He, C. et al. Nocturnal heat exposure and stroke risk. Eur. Heart J. 45, 2158–2166 (2024). (PMID: 3876895811212822)
      Coughlin, S. S. Recall bias in epidemiologic studies. J. Clin. Epidemiol. 43, 87–91 (1990). (PMID: 2319285)
      Petrou, S., Murray, L., Cooper, P. & Davidson, L. L. The accuracy of self-reported healthcare resource utilization in health economic studies. Int. J. Technol. Assess. Health Care. 18, 705–710 (2002). (PMID: 12391960)
      Heuschmann, P. U. et al. Incidence of stroke in Europe at the beginning of the 21st century. Stroke 40, 1557–1563 (2009). (PMID: 19325154)
      Hillmann, S. & ADSR). Stroke unit care in Germany: the German stroke registers study group ( (2017).
      Espárrago Llorca, G., Castilla-Guerra, L., Fernández Moreno, M. C. & Doblado, R. Jiménez hernández, M. D. Post-stroke depression: an update. Neurologia (Barcelona Spain). 30, 23–31 (2015). (PMID: 22901370)
      Kolominsky-Rabas, P. L. et al. Lifetime cost of ischemic stroke in germany: results and National projections from a population-based stroke registry: the Erlangen stroke project. Stroke 37, 1179–1183 (2006). (PMID: 16574918)
    • Contributed Indexing:
      Keywords: Cohort study; Depressiveness; Healthcare utilization; Post-stroke depression; Stroke
    • Publication Date:
      Date Created: 20250802 Date Completed: 20250802 Latest Revision: 20250807
    • Publication Date:
      20250808
    • Accession Number:
      PMC12318013
    • Accession Number:
      10.1038/s41598-025-12875-x
    • Accession Number:
      40753106