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Factors Influencing Quality of Life in Myasthenia Gravis Patients: Results From a Cross-Sectional Study in South of Iran.

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  • Additional Information
    • Source:
      Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101570837 Publication Model: Print Cited Medium: Internet ISSN: 2162-3279 (Electronic) NLM ISO Abbreviation: Brain Behav Subsets: MEDLINE
    • Publication Information:
      Original Publication: Hoboken, NJ : John Wiley & Sons
    • Subject Terms:
      Myasthenia Gravis*/psychology ; Myasthenia Gravis*/physiopathology ; Quality of Life*/psychology; Activities of Daily Living/psychology ; Fatigue/psychology ; Stress, Psychological/psychology ; Depression/psychology ; Humans ; Male ; Cross-Sectional Studies ; Female ; Middle Aged ; Adult ; Iran ; Aged ; Severity of Illness Index ; Surveys and Questionnaires
    • Abstract:
      Background: Myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction characterized by fatigue and muscle weakness, often leading to significant impairments in quality of life (QOL). This single-center cross-sectional study investigated factors influencing QOL among MG patients.
      Methods: Fifty-two participants diagnosed with MG were assessed using the MG Foundation of America (MGFA) classification and the MG composite (MGC) scale for disease severity. Patients completed validated questionnaires, including the Fatigue Severity Scale (FSS), Beck Depression Inventory (BDI), MG Activities of Daily Living (MG-ADL), and the MG Quality of Life 15-item scale (MG-QOL). Family stress levels were self-reported and categorized as "Rarely/Never," "Sometimes," "Often," or "Always."
      Results: The analysis revealed no significant differences in QOL scores based on sex, disease type, presenting symptoms, thymectomy status, or BMI. Employed or freelance patients exhibited significantly lower QOL and higher fatigue compared to retired or housewife groups. Higher family stress correlated with increased fatigue, worse MGC scores, and poorer QOL. Regression analysis identified the MG-ADL and FSS scores as the strongest predictors of QOL.
      Conclusion: QOL in MG is influenced by complex interactions among functional, social, and occupational factors. These findings emphasize the need for tailored interventions to address fatigue and support occupational and familial well-being in MG patients. Further research with larger cohorts is warranted to refine these insights and guide clinical strategies.
      (© 2025 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.)
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    • Grant Information:
      24077 Shiraz University of Medical Sciences
    • Contributed Indexing:
      Keywords: Activities of Daily Living (ADL); depression; fatigue; myasthenia gravis; quality of life
    • Publication Date:
      Date Created: 20250822 Date Completed: 20250822 Latest Revision: 20250827
    • Publication Date:
      20260130
    • Accession Number:
      PMC12370847
    • Accession Number:
      10.1002/brb3.70680
    • Accession Number:
      40842108